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@ARTICLE{Parmar:142509,
      author       = {P. Parmar and E. Lowry and G. Cugliari and M. Suderman and
                      R. Wilson and V. Karhunen and T. Andrew and P. Wiklund and
                      M. Wielscher and S. Guarrera and A. Teumer and B. Lehne and
                      L. Milani and N. de Klein and P. P. Mishra and P. E. Melton
                      and P. R. Mandaviya and S. Kasela and J. Nano and W. Zhang
                      and Y. Zhang and A. G. Uitterlinden and A. Peters and B.
                      Schöttker$^*$ and C. Gieger and D. Anderson and D. I.
                      Boomsma and H. J. Grabe and S. Panico and J. H. Veldink and
                      J. B. J. van Meurs and L. van den Berg and L. J. Beilin and
                      L. Franke and M. Loh and M. M. J. van Greevenbroek and M.
                      Nauck and M. Kähönen and M. A. Hurme and O. T. Raitakari
                      and O. H. Franco and P. E. Slagboom and P. van der Harst and
                      S. Kunze and S. B. Felix and T. Zhang and W. Chen and T. A.
                      Mori and A. Bonnefond and B. T. Heijmans and T. Muka and J.
                      S. Kooner and K. Fischer and M. Waldenberger and P. Froguel
                      and R.-C. Huang and T. Lehtimäki and W. Rathmann and C. L.
                      Relton and G. Matullo and H. Brenner$^*$ and N. Verweij and
                      S. Li and J. C. Chambers and M.-R. Järvelin and S. Sebert},
      collaboration = {B. Consortium and G. M. Q. Consortium},
      title        = {{A}ssociation of maternal prenatal smoking {GFI}1-locus and
                      cardio-metabolic phenotypes in 18,212 adults.},
      journal      = {EBioMedicine},
      volume       = {38},
      issn         = {2352-3964},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier},
      reportid     = {DKFZ-2019-00227},
      pages        = {206 - 216},
      year         = {2018},
      abstract     = {DNA methylation at the GFI1-locus has been repeatedly
                      associated with exposure to smoking from the foetal period
                      onwards. We explored whether DNA methylation may be a
                      mechanism that links exposure to maternal prenatal smoking
                      with offspring's adult cardio-metabolic health.We
                      meta-analysed the association between DNA methylation at
                      GFI1-locus with maternal prenatal smoking, adult own
                      smoking, and cardio-metabolic phenotypes in 22
                      population-based studies from Europe, Australia, and USA
                      (n = 18,212). DNA methylation at the GFI1-locus was
                      measured in whole-blood. Multivariable regression models
                      were fitted to examine its association with exposure to
                      prenatal and own adult smoking. DNA methylation levels were
                      analysed in relation to body mass index (BMI), waist
                      circumference (WC), fasting glucose (FG), high-density
                      lipoprotein cholesterol (HDL-C), triglycerides (TG),
                      diastolic, and systolic blood pressure (BP).Lower DNA
                      methylation at three out of eight GFI1-CpGs was associated
                      with exposure to maternal prenatal smoking, whereas, all
                      eight CpGs were associated with adult own smoking. Lower DNA
                      methylation at cg14179389, the strongest maternal prenatal
                      smoking locus, was associated with increased WC and BP when
                      adjusted for sex, age, and adult smoking with
                      Bonferroni-corrected P < 0·012. In contrast, lower DNA
                      methylation at cg09935388, the strongest adult own smoking
                      locus, was associated with decreased BMI, WC, and BP
                      (adjusted 1 × 10-7 < P < 0.01). Similarly,
                      lower DNA methylation at cg12876356, cg18316974, cg09662411,
                      and cg18146737 was associated with decreased BMI and WC
                      (5 × 10-8 < P < 0.001). Lower DNA methylation
                      at all the CpGs was consistently associated with higher TG
                      levels.Epigenetic changes at the GFI1 were linked to smoking
                      exposure in-utero/in-adulthood and robustly associated with
                      cardio-metabolic risk factors. FUND: European Union's
                      Horizon 2020 research and innovation programme under grant
                      agreement no. 633595 DynaHEALTH.},
      cin          = {C070 / G110},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331 / I:(DE-He78)G110-20160331},
      pnm          = {323 - Metabolic Dysfunction as Risk Factor (POF3-323)},
      pid          = {G:(DE-HGF)POF3-323},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30442561},
      pmc          = {pmc:PMC6306313},
      doi          = {10.1016/j.ebiom.2018.10.066},
      url          = {https://inrepo02.dkfz.de/record/142509},
}