%0 Journal Article
%A Weberpals, Janick
%A Jansen, Lina
%A Müller, Oliver J
%A Brenner, Hermann
%T Long-term heart-specific mortality among 347 476 breast cancer patients treated with radiotherapy or chemotherapy: a registry-based cohort study.
%J European heart journal
%V 39
%N 43
%@ 1522-9645
%C Oxford
%I Oxford University Press
%M DKFZ-2019-00308
%P 3896 - 3903
%D 2018
%X Breast cancer survival has improved throughout the last decades, but treatment-induced cardiotoxicity remains a major concern. This study aimed to investigate competing causes of death and prognostic factors within a large cohort of breast cancer patients and to describe the heart-specific mortality in relation to the general population.In this registry-based cohort study, women diagnosed with breast cancer between 2000 and 2011, who were treated with radiotherapy or chemotherapy and followed until 2014, were identified from the Surveillance, Epidemiology, and End Results-18 (SEER-18) database. Cumulative mortality functions were computed. To investigate heart-specific mortality relative to the general population, long-term (≥10 years) standardized mortality ratios (SMRs) were calculated. Prognostic factors for heart-specific mortality were assessed by calculating cause-specific hazard ratios (HRcs) with corresponding 95
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:29635274
%R 10.1093/eurheartj/ehy167
%U https://inrepo02.dkfz.de/record/142590