TY  - JOUR
AU  - Nowak, Johannes
AU  - Nemes, Karolina
AU  - Hohm, Annika
AU  - Vandergrift, Lindsey A
AU  - Hasselblatt, Martin
AU  - Johann, Pascal
AU  - Kool, Marcel
AU  - Frühwald, Michael C
AU  - Warmuth-Metz, Monika
TI  - Magnetic resonance imaging surrogates of molecular subgroups in atypical teratoid/rhabdoid tumor.
JO  - Neuro-Oncology
VL  - 20
IS  - 12
SN  - 1523-5866
CY  - Oxford
PB  - Oxford Univ. Press
M1  - DKFZ-2019-00330
SP  - 1672 - 1679
PY  - 2018
AB  - Recently, 3 molecular subgroups of atypical teratoid/rhabdoid tumor (ATRT) were identified, but little is known of their clinical and magnetic resonance imaging (MRI) characteristics.A total of 43 patients with known molecular subgroup status (ATRT-sonic hedgehog [SHH], n = 17; ATRT-tyrosine [TYR], n = 16; ATRT-myelocytomatosis oncogene [MYC], n = 10) were retrieved from the EU-RHAB Registry and analyzed for clinical and MRI features.On MRI review, differences in preferential tumor location were confirmed, with ATRT-TYR being predominantly located infratentorially (P < 0.05). Peritumoral edema was more pronounced in ATRT-MYC compared with ATRT-SHH (P < 0.05) and ATRT-TYR (P < 0.05). Conversely, peripheral tumor cysts were found more frequently in ATRT-SHH (71
LB  - PUB:(DE-HGF)16
C6  - pmid:30010851
C2  - pmc:PMC6231209
DO  - DOI:10.1093/neuonc/noy111
UR  - https://inrepo02.dkfz.de/record/142612
ER  -