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@ARTICLE{Nowak:142612,
      author       = {J. Nowak and K. Nemes and A. Hohm and L. A. Vandergrift and
                      M. Hasselblatt and P. Johann$^*$ and M. Kool$^*$ and M. C.
                      Frühwald and M. Warmuth-Metz},
      title        = {{M}agnetic resonance imaging surrogates of molecular
                      subgroups in atypical teratoid/rhabdoid tumor.},
      journal      = {Neuro-Oncology},
      volume       = {20},
      number       = {12},
      issn         = {1523-5866},
      address      = {Oxford},
      publisher    = {Oxford Univ. Press},
      reportid     = {DKFZ-2019-00330},
      pages        = {1672 - 1679},
      year         = {2018},
      abstract     = {Recently, 3 molecular subgroups of atypical
                      teratoid/rhabdoid tumor (ATRT) were identified, but little
                      is known of their clinical and magnetic resonance imaging
                      (MRI) characteristics.A total of 43 patients with known
                      molecular subgroup status (ATRT-sonic hedgehog [SHH], n =
                      17; ATRT-tyrosine [TYR], n = 16; ATRT-myelocytomatosis
                      oncogene [MYC], n = 10) were retrieved from the EU-RHAB
                      Registry and analyzed for clinical and MRI features.On MRI
                      review, differences in preferential tumor location were
                      confirmed, with ATRT-TYR being predominantly located
                      infratentorially (P < 0.05). Peritumoral edema was more
                      pronounced in ATRT-MYC compared with ATRT-SHH (P < 0.05) and
                      ATRT-TYR (P < 0.05). Conversely, peripheral tumor cysts were
                      found more frequently in ATRT-SHH $(71\%)$ and ATRT-TYR
                      $(94\%)$ compared with ATRT-MYC $(40\%,$ P < 0.05). Contrast
                      enhancement was absent in $29\%$ of ATRT-SHH $(0\%$ of
                      ATRT-TYR; $10\%$ of ATRT-MYC; P < 0.05), and there was a
                      trend toward strong contrast enhancement in ATRT-TYR and
                      ATRT-MYC. We found the characteristic (bandlike) enhancement
                      in $28\%$ of ATRT as well as restricted diffusion in the
                      majority of tumors. A midline/off-midline location in the
                      posterior fossa was also not subgroup specific. Visible
                      meningeal spread (M2) at diagnosis was rare throughout all
                      subgroups.These exploratory findings suggest that MRI
                      features vary across the 3 molecular subgroups of ATRT.
                      Within future prospective trials, MRI may aid diagnosis and
                      treatment stratification.},
      cin          = {B062 / L101},
      ddc          = {610},
      cid          = {I:(DE-He78)B062-20160331 / I:(DE-He78)L101-20160331},
      pnm          = {312 - Functional and structural genomics (POF3-312)},
      pid          = {G:(DE-HGF)POF3-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30010851},
      pmc          = {pmc:PMC6231209},
      doi          = {10.1093/neuonc/noy111},
      url          = {https://inrepo02.dkfz.de/record/142612},
}