% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Raposo:142744,
      author       = {B. Raposo and P. Merky and C. Lundqvist and H. Yamada and
                      V. Urbonaviciute and C. Niaudet and J. Viljanen and J.
                      Kihlberg and B. Kyewski$^*$ and O. Ekwall and R. Holmdahl
                      and J. Bäcklund},
      title        = {{T} cells specific for post-translational modifications
                      escape intrathymic tolerance induction.},
      journal      = {Nature Communications},
      volume       = {9},
      number       = {1},
      issn         = {2041-1723},
      address      = {[London]},
      publisher    = {Nature Publishing Group UK},
      reportid     = {DKFZ-2019-00461},
      pages        = {353},
      year         = {2018},
      abstract     = {Establishing effective central tolerance requires the
                      promiscuous expression of tissue-restricted antigens by
                      medullary thymic epithelial cells. However, whether central
                      tolerance also extends to post-translationally modified
                      proteins is not clear. Here we show a mouse model of
                      autoimmunity in which disease development is dependent on
                      post-translational modification (PTM) of
                      the tissue-restricted self-antigen collagen type II. T
                      cells specific for the non-modified antigen undergo
                      efficient central tolerance. By contrast, PTM-reactive T
                      cells escape thymic selection, though the PTM variant
                      constitutes the dominant form in the periphery. This finding
                      implies that the PTM protein is absent in the thymus, or
                      present at concentrations insufficient to induce negative
                      selection of developing thymocytes and explains the lower
                      level of tolerance induction against the PTM antigen. As the
                      majority of self-antigens are post-translationally modified,
                      these data raise the possibility that T cells specific for
                      other self-antigens naturally subjected to PTM may escape
                      central tolerance induction by a similar mechanism.},
      keywords     = {Autoantigens (NLM Chemicals) / Collagen Type II (NLM
                      Chemicals)},
      cin          = {D090},
      ddc          = {500},
      cid          = {I:(DE-He78)D090-20160331},
      pnm          = {314 - Tumor immunology (POF3-314)},
      pid          = {G:(DE-HGF)POF3-314},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29367624},
      pmc          = {pmc:PMC5783942},
      doi          = {10.1038/s41467-017-02763-y},
      url          = {https://inrepo02.dkfz.de/record/142744},
}