TY  - JOUR
AU  - Lablans, Martin
AU  - Schmidt, Esther
AU  - Ückert, Frank
TI  - An Architecture for Translational Cancer Research As Exemplified by the German Cancer Consortium.
JO  - JCO clinical cancer informatics
VL  - 2
IS  - 2
SN  - 2473-4276
CY  - Alexandria, VA
PB  - American Society of Clinical Oncology
M1  - DKFZ-2019-00464
SP  - 1 - 8
PY  - 2018
N1  - JCO Clinical Cancer Informatics = 2473-4276 (import from CrossRef, PubMed, )
AB  - Networking of medical institutions by means of a capable data infrastructure has the potential to open up vast amounts of routine data to translational cancer research. However, the secondary use of information collected independently in several institutions is a challenging task of data integration. In this review, we discuss the requirements and common challenges involved in the establishment of such a platform. We present methods and tools from the field of medical informatics as solutions to semantic and technical heterogeneity, questions of data protection and record linkage, as well as issues of trust and data ownership. We also describe the architecture of an existing cancer research network as an exemplary application of these methods.
LB  - PUB:(DE-HGF)16
C6  - pmid:30652543
DO  - DOI:10.1200/CCI.17.00062
UR  - https://inrepo02.dkfz.de/record/142747
ER  -