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@ARTICLE{Alwers:142855,
      author       = {E. Alwers$^*$ and M. Jia$^*$ and M. Kloor and H. Bläker
                      and H. Brenner$^*$ and M. Hoffmeister$^*$},
      title        = {{A}ssociations {B}etween {M}olecular {C}lassifications of
                      {C}olorectal {C}ancer and {P}atient {S}urvival: {A}
                      {S}ystematic {R}eview.},
      journal      = {Clinical gastroenterology and hepatology},
      volume       = {17},
      number       = {3},
      issn         = {1542-3565},
      address      = {New York, NY},
      publisher    = {Elsevier Science},
      reportid     = {DKFZ-2019-00485},
      pages        = {402 - 410.e2},
      year         = {2019},
      abstract     = {Colorectal cancer (CRC) is a heterogeneous disease with
                      different mechanisms of pathogenesis. Classification systems
                      have been proposed based on molecular features of tumors,
                      but none are used in clinical practice. We performed a
                      systematic review of studies on the associations between
                      molecular classifications of CRC and patient survival.We
                      searched the PubMed, Embase, Cochrane, and Web of Science
                      databases for combinations of terms related to CRC,
                      molecular markers, subtype classifications, and survival
                      (overall survival, disease-specific survival, disease-free
                      survival). We included only studies that used at least 3
                      molecular markers to classify tumors and provided an
                      estimate of survival associated with each subtype. Data
                      extraction and quality assessment were performed
                      independently by 2 reviewers.We identified 6 studies that
                      fulfilled the inclusion criteria. In these studies,
                      molecular subtypes were assigned based on pathways
                      associated with tumor development or findings from gene
                      expression clustering analyses. Most studies proposed
                      classification systems with 5 subtypes, including
                      information on microsatellite instability, mutations in
                      BRAF, and mutations in KRAS. None of the studies included
                      TNM stage in their classification system. Three
                      classification systems used similar definitions. Only 3
                      studies provided internal or external validation of the
                      proposed classification schemes. Tumors with microsatellite
                      stability and mutations in KRAS or BRAF were associated with
                      decreased survival times, compared with tumors with
                      microsatellite stability and no mutations.In a systematic
                      review of studies of molecular classifications of CRC and
                      patient survival, we found that most subtypes were not
                      significantly or not differentially associated with
                      survival. None of the systems integrated TNM staging.
                      Further research and validation are needed to develop
                      molecular subtype classification systems for clinical
                      practice.},
      subtyp        = {Review Article},
      cin          = {C070 / C120},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331 / I:(DE-He78)C120-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29306042},
      doi          = {10.1016/j.cgh.2017.12.038},
      url          = {https://inrepo02.dkfz.de/record/142855},
}