TY  - JOUR
AU  - Bläker, Hendrik
AU  - Alwers, Elizabeth
AU  - Arnold, Alexander
AU  - Herpel, Esther
AU  - Tagscherer, Katrin E
AU  - Roth, Wilfried
AU  - Jansen, Lina
AU  - Walter, Viola
AU  - Kloor, Matthias
AU  - Chang-Claude, Jenny
AU  - Brenner, Hermann
AU  - Hoffmeister, Michael
TI  - The Association Between Mutations in BRAF and Colorectal Cancer-Specific Survival Depends on Microsatellite Status and Tumor Stage.
JO  - Clinical gastroenterology and hepatology
VL  - 17
IS  - 3
SN  - 1542-3565
CY  - New York, NY
PB  - Elsevier Science
M1  - DKFZ-2019-00487
SP  - 455 - 462.e6
PY  - 2019
AB  - Colorectal tumors with mutations in BRAF and microsatellite stability (MSS) have been associated with adverse outcomes of patients. Combined tests for microsatellite instability-high (MSI-H) and BRAF mutations might therefore be used in risk assessment, particularly for patients with stage II tumors. We investigate the stage-specific prognostic value of combined testing for MSI-H and BRAF for patients with colorectal cancer.We performed a retrospective analysis of colorectal tumor samples collected from 1995 patients at 22 hospitals in Germany, between 2003 and 2010. Samples were analyzed for MSI-H using an established mononucleotide marker panel; BRAF mutations (BRAFV600E) were detected by Sanger sequencing or in tissue microarray blocks using immunohistochemistry. Cancers were assigned to categories of having MSS without mutations in BRAF, MSS with mutant BRAF, MSI-H without mutations in BRAF, and MSI-H with mutant BRAF. We investigated the association between tumor categories with clinical and pathologic features and patient's overall, disease-specific, and recurrence-free survival (median follow-up time, 5.1 y).Tumors were stage I in 364 (18
LB  - PUB:(DE-HGF)16
C6  - pmid:29660527
DO  - DOI:10.1016/j.cgh.2018.04.015
UR  - https://inrepo02.dkfz.de/record/142857
ER  -