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000142859 1001_ $$aCampa, Daniele$$b0
000142859 245__ $$aGenetic polymorphisms in genes of class switch recombination and multiple myeloma risk and survival: an IMMEnSE study.
000142859 260__ $$aLondon [u.a.]$$bTaylor & Francis Group$$c2019
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000142859 520__ $$aGenetic variants in genes acting during the maturation process of immature B-cell to differentiated plasma cell could influence the risk of developing multiple myeloma (MM). During B-cell maturation, several programmed genetic rearrangements occur to increase the variation of the immunoglobulin chains. Class switch recombination (CSR) is one of the most important among these mechanisms. Germline polymorphisms altering even subtly this process could play a role in the etiology and outcome of MM. We performed an association study of 30 genetic variants in the key CSR genes, using 2632 MM patients and 2848 controls from the International Multiple Myeloma rESEarch (IMMEnSE) consortium, the Heidelberg MM Group and the ESTHER cohort. We found an association between LIG4-rs1555902 and decreased MM risk, which approached statistical significance, as well as significant associations between AICDA-rs3794318 and better outcome. Our results add to our knowledge on the genetic component of MM risk and survival.
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000142859 7001_ $$0P:(DE-HGF)0$$aMartino, Alessandro$$b1
000142859 7001_ $$0P:(DE-He78)b791a47b92809f7c54501331f72e0243$$aMacauda, Angelica$$b2$$udkfz
000142859 7001_ $$aDudziński, Marek$$b3
000142859 7001_ $$aSuska, Anna$$b4
000142859 7001_ $$aDruzd-Sitek, Agnieszka$$b5
000142859 7001_ $$0P:(DE-He78)1cb537e833afd985097ccfaddffb2ef3$$aRaab, Marc-Steffen$$b6$$udkfz
000142859 7001_ $$00000-0002-2818-5487$$aMoreno, Victor$$b7
000142859 7001_ $$aHuhn, Stefanie$$b8
000142859 7001_ $$aButrym, Aleksandra$$b9
000142859 7001_ $$aSainz, Juan$$b10
000142859 7001_ $$aSzombath, Gergely$$b11
000142859 7001_ $$aRymko, Marcin$$b12
000142859 7001_ $$aMarques, Herlander$$b13
000142859 7001_ $$aLesueur, Fabienne$$b14
000142859 7001_ $$aVangsted, Annette Juul$$b15
000142859 7001_ $$aVogel, Ulla$$b16
000142859 7001_ $$aKruszewski, Marcin$$b17
000142859 7001_ $$aSubocz, Edyta$$b18
000142859 7001_ $$aBuda, Gabriele$$b19
000142859 7001_ $$aIskierka-Jażdżewska, Elżbieta$$b20
000142859 7001_ $$aRíos, Rafael$$b21
000142859 7001_ $$aMerz, Maximilian$$b22
000142859 7001_ $$0P:(DE-He78)c67a12496b8aac150c0eef888d808d46$$aSchöttker, Ben$$b23$$udkfz
000142859 7001_ $$aMazur, Grzegorz$$b24
000142859 7001_ $$aPerrial, Emeline$$b25
000142859 7001_ $$00000-0001-7908-0063$$aMartinez-Lopez, Joaquin$$b26
000142859 7001_ $$aButterbach, Katja$$b27
000142859 7001_ $$aGarcía Sanz, Ramón$$b28
000142859 7001_ $$aGoldschmidt, Hartmut$$b29
000142859 7001_ $$0P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2$$aBrenner, Hermann$$b30$$udkfz
000142859 7001_ $$aJamroziak, Krzysztof$$b31
000142859 7001_ $$aReis, Rui Manuel$$b32
000142859 7001_ $$aKadar, Katalin$$b33
000142859 7001_ $$aDumontet, Charles$$b34
000142859 7001_ $$aWątek, Marzena$$b35
000142859 7001_ $$aHaastrup, Eva Kannik$$b36
000142859 7001_ $$aHelbig, Grzegorz$$b37
000142859 7001_ $$aJurczyszyn, Artur$$b38
000142859 7001_ $$aJerez, Andrés$$b39
000142859 7001_ $$aVarkonyi, Judit$$b40
000142859 7001_ $$00000-0001-6968-148X$$aBarington, Torben$$b41
000142859 7001_ $$aGrzasko, Norbert$$b42
000142859 7001_ $$aZaucha, Jan Maciej$$b43
000142859 7001_ $$aAndersen, Vibeke$$b44
000142859 7001_ $$aZawirska, Daria$$b45
000142859 7001_ $$0P:(DE-He78)5323704270b6393dcea70186ffd86bca$$aCanzian, Federico$$b46$$eLast author$$udkfz
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