TY  - JOUR
AU  - Campa, Daniele
AU  - Martino, Alessandro
AU  - Macauda, Angelica
AU  - Dudziński, Marek
AU  - Suska, Anna
AU  - Druzd-Sitek, Agnieszka
AU  - Raab, Marc-Steffen
AU  - Moreno, Victor
AU  - Huhn, Stefanie
AU  - Butrym, Aleksandra
AU  - Sainz, Juan
AU  - Szombath, Gergely
AU  - Rymko, Marcin
AU  - Marques, Herlander
AU  - Lesueur, Fabienne
AU  - Vangsted, Annette Juul
AU  - Vogel, Ulla
AU  - Kruszewski, Marcin
AU  - Subocz, Edyta
AU  - Buda, Gabriele
AU  - Iskierka-Jażdżewska, Elżbieta
AU  - Ríos, Rafael
AU  - Merz, Maximilian
AU  - Schöttker, Ben
AU  - Mazur, Grzegorz
AU  - Perrial, Emeline
AU  - Martinez-Lopez, Joaquin
AU  - Butterbach, Katja
AU  - García Sanz, Ramón
AU  - Goldschmidt, Hartmut
AU  - Brenner, Hermann
AU  - Jamroziak, Krzysztof
AU  - Reis, Rui Manuel
AU  - Kadar, Katalin
AU  - Dumontet, Charles
AU  - Wątek, Marzena
AU  - Haastrup, Eva Kannik
AU  - Helbig, Grzegorz
AU  - Jurczyszyn, Artur
AU  - Jerez, Andrés
AU  - Varkonyi, Judit
AU  - Barington, Torben
AU  - Grzasko, Norbert
AU  - Zaucha, Jan Maciej
AU  - Andersen, Vibeke
AU  - Zawirska, Daria
AU  - Canzian, Federico
TI  - Genetic polymorphisms in genes of class switch recombination and multiple myeloma risk and survival: an IMMEnSE study.
JO  - Leukemia and lymphoma
VL  - 60
IS  - 7
SN  - 1029-2403
CY  - London [u.a.]
PB  - Taylor & Francis Group
M1  - DKFZ-2019-00489
SP  - 1803-1811
PY  - 2019
AB  - Genetic variants in genes acting during the maturation process of immature B-cell to differentiated plasma cell could influence the risk of developing multiple myeloma (MM). During B-cell maturation, several programmed genetic rearrangements occur to increase the variation of the immunoglobulin chains. Class switch recombination (CSR) is one of the most important among these mechanisms. Germline polymorphisms altering even subtly this process could play a role in the etiology and outcome of MM. We performed an association study of 30 genetic variants in the key CSR genes, using 2632 MM patients and 2848 controls from the International Multiple Myeloma rESEarch (IMMEnSE) consortium, the Heidelberg MM Group and the ESTHER cohort. We found an association between LIG4-rs1555902 and decreased MM risk, which approached statistical significance, as well as significant associations between AICDA-rs3794318 and better outcome. Our results add to our knowledge on the genetic component of MM risk and survival.
LB  - PUB:(DE-HGF)16
C6  - pmid:30633655
DO  - DOI:10.1080/10428194.2018.1551536
UR  - https://inrepo02.dkfz.de/record/142859
ER  -