TY  - JOUR
AU  - Erkek, Serap
AU  - Johann, Pascal
AU  - Finetti, Martina A
AU  - Drosos, Yiannis
AU  - Chou, Hsien-Chao
AU  - Zapatka, Marc
AU  - Sturm, Dominik
AU  - Jones, David
AU  - Korshunov, Andrey
AU  - Rhyzova, Marina
AU  - Wolf, Stephan
AU  - Mallm, Jan-Philipp
AU  - Beck, Katja
AU  - Witt, Olaf
AU  - Kulozik, Andreas E
AU  - Frühwald, Michael C
AU  - Northcott, Paul A
AU  - Korbel, Jan O
AU  - Lichter, Peter
AU  - Eils, Roland
AU  - Gajjar, Amar
AU  - Roberts, Charles W M
AU  - Williamson, Daniel
AU  - Hasselblatt, Martin
AU  - Chavez, Lukas
AU  - Pfister, Stefan
AU  - Kool, Marcel
TI  - Comprehensive Analysis of Chromatin States in Atypical Teratoid/Rhabdoid Tumor Identifies Diverging Roles for SWI/SNF and Polycomb in Gene Regulation.
JO  - Cancer cell
VL  - 35
IS  - 1
SN  - 1535-6108
CY  - New York, NY
PB  - Elsevier
M1  - DKFZ-2019-00496
SP  - 95 - 110.e8
PY  - 2019
AB  - Biallelic inactivation of SMARCB1, encoding a member of the SWI/SNF chromatin remodeling complex, is the hallmark genetic aberration of atypical teratoid rhabdoid tumors (ATRT). Here, we report how loss of SMARCB1 affects the epigenome in these tumors. Using chromatin immunoprecipitation sequencing (ChIP-seq) on primary tumors for a series of active and repressive histone marks, we identified the chromatin states differentially represented in ATRTs compared with other brain tumors and non-neoplastic brain. Re-expression of SMARCB1 in ATRT cell lines enabled confirmation of our genome-wide findings for the chromatin states. Additional generation of ChIP-seq data for SWI/SNF and Polycomb group proteins and the transcriptional repressor protein REST determined differential dependencies of SWI/SNF and Polycomb complexes in regulation of diverse gene sets in ATRTs.
LB  - PUB:(DE-HGF)16
C6  - pmid:30595504
C2  - pmc:PMC6341227
DO  - DOI:10.1016/j.ccell.2018.11.014
UR  - https://inrepo02.dkfz.de/record/142866
ER  -