%0 Journal Article
%A Gündert, Melanie
%A Edelmann, Dominic
%A Benner, Axel
%A Jansen, Lina
%A Jia, Min
%A Walter, Viola
%A Knebel, Phillip
%A Herpel, Esther
%A Chang-Claude, Jenny
%A Hoffmeister, Michael
%A Brenner, Hermann
%A Burwinkel, Barbara
%T Genome-wide DNA methylation analysis reveals a prognostic classifier for non-metastatic colorectal cancer (ProMCol classifier).
%J Gut
%V 68
%N 1
%@ 1468-3288
%C London
%I BMJ Publishing Group
%M DKFZ-2019-00498
%P 101 - 110
%D 2019
%X Pathological staging used for the prediction of patient survival in colorectal cancer (CRC) provides only limited information.Here, a genome-wide study of DNA methylation was conducted for two cohorts of patients with non-metastatic CRC (screening cohort (n=572) and validation cohort (n=274)). A variable screening for prognostic CpG sites was performed in the screening cohort using marginal testing based on a Cox model and subsequent adjustment of the p-values via independent hypothesis weighting using the methylation difference between 34 pairs of tumour and normal mucosa tissue as auxiliary covariate. From the 1000 CpG sites with the smallest adjusted p-value, 20 CpG sites with the smallest Brier score for overall survival (OS) were selected. Applying principal component analysis, we derived a prognostic methylation-based classifier for patients with non-metastatic CRC (ProMCol classifier).This classifier was associated with OS in the screening (HR 0.51, 95
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:29101262
%R 10.1136/gutjnl-2017-314711
%U https://inrepo02.dkfz.de/record/142868