TY  - JOUR
AU  - Gündert, Melanie
AU  - Edelmann, Dominic
AU  - Benner, Axel
AU  - Jansen, Lina
AU  - Jia, Min
AU  - Walter, Viola
AU  - Knebel, Phillip
AU  - Herpel, Esther
AU  - Chang-Claude, Jenny
AU  - Hoffmeister, Michael
AU  - Brenner, Hermann
AU  - Burwinkel, Barbara
TI  - Genome-wide DNA methylation analysis reveals a prognostic classifier for non-metastatic colorectal cancer (ProMCol classifier).
JO  - Gut
VL  - 68
IS  - 1
SN  - 1468-3288
CY  - London
PB  - BMJ Publishing Group
M1  - DKFZ-2019-00498
SP  - 101 - 110
PY  - 2019
AB  - Pathological staging used for the prediction of patient survival in colorectal cancer (CRC) provides only limited information.Here, a genome-wide study of DNA methylation was conducted for two cohorts of patients with non-metastatic CRC (screening cohort (n=572) and validation cohort (n=274)). A variable screening for prognostic CpG sites was performed in the screening cohort using marginal testing based on a Cox model and subsequent adjustment of the p-values via independent hypothesis weighting using the methylation difference between 34 pairs of tumour and normal mucosa tissue as auxiliary covariate. From the 1000 CpG sites with the smallest adjusted p-value, 20 CpG sites with the smallest Brier score for overall survival (OS) were selected. Applying principal component analysis, we derived a prognostic methylation-based classifier for patients with non-metastatic CRC (ProMCol classifier).This classifier was associated with OS in the screening (HR 0.51, 95
LB  - PUB:(DE-HGF)16
C6  - pmid:29101262
DO  - DOI:10.1136/gutjnl-2017-314711
UR  - https://inrepo02.dkfz.de/record/142868
ER  -