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| 100 | 1 | _ | |a Gündert, Melanie |0 P:(DE-HGF)0 |b 0 |e First author |
| 245 | _ | _ | |a Genome-wide DNA methylation analysis reveals a prognostic classifier for non-metastatic colorectal cancer (ProMCol classifier). |
| 260 | _ | _ | |a London |c 2019 |b BMJ Publishing Group |
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| 520 | _ | _ | |a Pathological staging used for the prediction of patient survival in colorectal cancer (CRC) provides only limited information.Here, a genome-wide study of DNA methylation was conducted for two cohorts of patients with non-metastatic CRC (screening cohort (n=572) and validation cohort (n=274)). A variable screening for prognostic CpG sites was performed in the screening cohort using marginal testing based on a Cox model and subsequent adjustment of the p-values via independent hypothesis weighting using the methylation difference between 34 pairs of tumour and normal mucosa tissue as auxiliary covariate. From the 1000 CpG sites with the smallest adjusted p-value, 20 CpG sites with the smallest Brier score for overall survival (OS) were selected. Applying principal component analysis, we derived a prognostic methylation-based classifier for patients with non-metastatic CRC (ProMCol classifier).This classifier was associated with OS in the screening (HR 0.51, 95% CI 0.41 to 0.63, p=6.2E-10) and the validation cohort (HR 0.61, 95% CI 0.45 to 0.82, p=0.001). The independent validation of the ProMCol classifier revealed a reduction of the prediction error for 3-year OS from 0.127, calculated only with standard clinical variables, to 0.120 combining the clinical variables with the classifier and for 4-year OS from 0.153 to 0.140. All results were confirmed for disease-specific survival.The ProMCol classifier could improve the prognostic accuracy for patients with non-metastatic CRC. |
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| 700 | 1 | _ | |a Knebel, Phillip |b 6 |
| 700 | 1 | _ | |a Herpel, Esther |b 7 |
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| 700 | 1 | _ | |a Burwinkel, Barbara |0 P:(DE-He78)15b7fd2bc02d5ef47a2fe2dd0140d2bf |b 11 |e Last author |u dkfz |
| 773 | _ | _ | |a 10.1136/gutjnl-2017-314711 |g Vol. 68, no. 1, p. 101 - 110 |0 PERI:(DE-600)1492637-4 |n 1 |p 101 - 110 |t Gut |v 68 |y 2019 |x 1468-3288 |
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