%0 Journal Article
%A Veldwijk, Marlon R
%A Seibold, Petra
%A Botma, Akke
%A Helmbold, Irmgard
%A Sperk, Elena
%A Giordano, Frank A
%A Gürth, Nicole
%A Kirchner, Anne
%A Behrens, Sabine
%A Wenz, Frederik
%A Chang-Claude, Jenny
%A Herskind, Carsten
%T Association of CD4+ Radiation-Induced Lymphocyte Apoptosis with Fibrosis and Telangiectasia after Radiotherapy in 272 Breast Cancer Patients with </td><td width="150">
%T gt;10-Year Follow-up.
%J Clinical cancer research
%V 25
%N 2
%@ 1557-3265
%C Philadelphia, Pa. [u.a.]
%I AACR
%M DKFZ-2019-00508
%P 562 - 572
%D 2019
%X Radiation-induced lymphocyte apoptosis (RILA) has been suggested as a predictive assay for adverse late reactions after radiotherapy. Thus, low RILA values of T-lymphocyte subpopulations have been associated with increased risk for various endpoints at 2 to 3 years of follow-up. The purpose was to test if such associations persist for specific endpoints (subcutaneous fibrosis, telangiectasia) in breast cancer patients with at least 10 years of follow-up.Experimental Design: Two hundred and seventy-two female patients who had received breast-conserving therapy within the German ISE study were included (median follow-up: 11.6 years). Radiotherapy-induced side effects were scored according to the Late Effects in Normal Tissues-Subjective, Objective, Management, and Analytic (LENT-SOMA) classification system. RILA in the CD4+, CD8+, and natural killer (NK) subpopulations from peripheral blood was analyzed by flow cytometry. Multivariate predictive modeling was performed including relevant clinical risk factors.Low CD4+ RILA was associated with increased risk for both fibrosis (P = 0.011) and telangiectasia (P < 0.001). For fibrosis, the association was stronger outside the surgical area (Fibout; P = 0.004) than within (Fibin; P = 0.17). Predictive multivariate modeling including clinical risk factors yielded OR of 3.48 (95
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:30327309
%R 10.1158/1078-0432.CCR-18-0777
%U https://inrepo02.dkfz.de/record/142878