TY  - JOUR
AU  - Veldwijk, Marlon R
AU  - Seibold, Petra
AU  - Botma, Akke
AU  - Helmbold, Irmgard
AU  - Sperk, Elena
AU  - Giordano, Frank A
AU  - Gürth, Nicole
AU  - Kirchner, Anne
AU  - Behrens, Sabine
AU  - Wenz, Frederik
AU  - Chang-Claude, Jenny
AU  - Herskind, Carsten
TI  - Association of CD4+ Radiation-Induced Lymphocyte Apoptosis with Fibrosis and Telangiectasia after Radiotherapy in 272 Breast Cancer Patients with </td><td width="150">
TI  - gt;10-Year Follow-up.
JO  - Clinical cancer research
VL  - 25
IS  - 2
SN  - 1557-3265
CY  - Philadelphia, Pa. [u.a.]
PB  - AACR
M1  - DKFZ-2019-00508
SP  - 562 - 572
PY  - 2019
AB  - Radiation-induced lymphocyte apoptosis (RILA) has been suggested as a predictive assay for adverse late reactions after radiotherapy. Thus, low RILA values of T-lymphocyte subpopulations have been associated with increased risk for various endpoints at 2 to 3 years of follow-up. The purpose was to test if such associations persist for specific endpoints (subcutaneous fibrosis, telangiectasia) in breast cancer patients with at least 10 years of follow-up.Experimental Design: Two hundred and seventy-two female patients who had received breast-conserving therapy within the German ISE study were included (median follow-up: 11.6 years). Radiotherapy-induced side effects were scored according to the Late Effects in Normal Tissues-Subjective, Objective, Management, and Analytic (LENT-SOMA) classification system. RILA in the CD4+, CD8+, and natural killer (NK) subpopulations from peripheral blood was analyzed by flow cytometry. Multivariate predictive modeling was performed including relevant clinical risk factors.Low CD4+ RILA was associated with increased risk for both fibrosis (P = 0.011) and telangiectasia (P < 0.001). For fibrosis, the association was stronger outside the surgical area (Fibout; P = 0.004) than within (Fibin; P = 0.17). Predictive multivariate modeling including clinical risk factors yielded OR of 3.48 (95
LB  - PUB:(DE-HGF)16
C6  - pmid:30327309
DO  - DOI:10.1158/1078-0432.CCR-18-0777
UR  - https://inrepo02.dkfz.de/record/142878
ER  -