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@ARTICLE{Raina:142882,
      author       = {P. Raina and A. Gilsing and H. Freisling and E. van den
                      Heuvel and N. Sohel and M. Jenab and P. Ferrari and A.
                      Tjønneland and V. Benetou and S. Picavet and S. Eriksson
                      and B. Schöttker$^*$ and H. Brenner$^*$ and K.-U. Saum$^*$
                      and L. Perna$^*$ and T. Wilsgaard and A. Trichopoulou and P.
                      Boffetta and L. E. Griffith},
      title        = {{T}he {C}ombined {E}ffect of {C}ancer and {C}ardiometabolic
                      {C}onditions on the {M}ortality {B}urden in {O}lder
                      {A}dults.},
      journal      = {The journals of gerontology / A Biological sciences,
                      medical sciences Series A},
      volume       = {74},
      number       = {3},
      issn         = {1758-535X},
      address      = {Oxford [u.a.]},
      publisher    = {Oxford Univ. Pr.},
      reportid     = {DKFZ-2019-00512},
      pages        = {366 - 372},
      year         = {2019},
      abstract     = {The number of older people living with cancer and
                      cardiometabolic conditions is increasing, but little is
                      known about how specific combinations of these conditions
                      impact mortality.A total of 22,692 participants aged 65
                      years and older from four international cohorts were
                      followed-up for mortality for an average of 10 years (8,596
                      deaths). Data were harmonized across cohorts and mutually
                      exclusive groups of disease combinations were created for
                      cancer, myocardial infarction (MI), stroke, and diabetes at
                      baseline. Cox proportional hazards models for all-cause
                      mortality were used to estimate the age- and sex-adjusted
                      hazard ratio and rate advancement period (RAP) (in years).At
                      baseline, $23.6\%$ (n = 5,116) of participants reported
                      having one condition and $4.2\%$ (n = 955) had two or more
                      conditions. Data from all studies combined showed that the
                      RAP increased with each additional condition. Diabetes
                      advanced the rate of dying by the most years (5.26 years;
                      $95\%$ confidence interval [CI], 4.53-6.00), but the effect
                      of any single condition was smaller than the effect of
                      disease combinations. Some combinations had a significantly
                      greater impact on the period by which the rate of death was
                      advanced than others with the same number of conditions, for
                      example, 10.9 years $(95\%$ CI, 9.4-12.6) for MI and
                      diabetes versus 6.4 years $(95\%$ CI, 4.3-8.5) for cancer
                      and diabetes.Combinations of cancer and cardiometabolic
                      conditions accelerate mortality rates in older adults
                      differently. Although most studies investigating mortality
                      associated with multimorbidity used disease counts, these
                      provide little guidance for managing complex patients as
                      they age.},
      cin          = {C070},
      ddc          = {570},
      cid          = {I:(DE-He78)C070-20160331},
      pnm          = {323 - Metabolic Dysfunction as Risk Factor (POF3-323)},
      pid          = {G:(DE-HGF)POF3-323},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29562321},
      doi          = {10.1093/gerona/gly053},
      url          = {https://inrepo02.dkfz.de/record/142882},
}