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@ARTICLE{Lefevre:142900,
      author       = {A. Lefevre$^*$ and R. Hurlemann and V. Grinevich$^*$},
      title        = {{I}maging neuropeptide effects on human brain function.},
      journal      = {Cell $\&$ tissue research},
      volume       = {375},
      number       = {1},
      issn         = {1432-0878},
      address      = {Heidelberg},
      publisher    = {Springer},
      reportid     = {DKFZ-2019-00530},
      pages        = {279 - 286},
      year         = {2019},
      abstract     = {The discovery of prosocial effects of oxytocin (OT) opened
                      new directions for studying neuropeptide effects on the
                      human brain. However, despite obvious effects of OT on
                      neural responses as reported in numerous studies, other
                      peptides have received less attention. Therefore, we will
                      only briefly summarize evidence of OT effects on human
                      functional magnetic resonance imaging (fMRI) and primarily
                      focus on OT's sister neuropeptide arginine-vasopressin by
                      presenting our own coordinated-based activation likelihood
                      estimation meta-analysis. In addition, we will recapitulate
                      rather limited data on few other neuropeptides, including
                      pharmacological and genetic fMRI studies. Finally, we will
                      review experiments with external neuropeptide administration
                      to patients afflicted with mental disorders, such as autism
                      or schizophrenia. In conclusion, despite remaining
                      uncertainty regarding the penetrance of exogenous
                      neuropeptides through the blood-brain barrier, it is evident
                      that neuropeptides simultaneously influence the activity of
                      limbic and cortical areas, indicating that these systems
                      have a good potential for therapeutic drug development.
                      Hence, this calls for further systematic studies of a wide
                      spectrum of known and less known neuropeptides to understand
                      their normal function in the brain and, subsequently, to
                      tackle their potential contribution for pathophysiological
                      mechanisms of mental disorders.},
      subtyp        = {Review Article},
      cin          = {V078},
      ddc          = {610},
      cid          = {I:(DE-He78)V078-20160331},
      pnm          = {319H - Addenda (POF3-319H)},
      pid          = {G:(DE-HGF)POF3-319H},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30069597},
      doi          = {10.1007/s00441-018-2899-6},
      url          = {https://inrepo02.dkfz.de/record/142900},
}