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000142910 1001_ $$00000-0002-9352-5927$$aMancuso, Nicholas$$b0
000142910 245__ $$aLarge-scale transcriptome-wide association study identifies new prostate cancer risk regions.
000142910 260__ $$a[London]$$bNature Publishing Group UK$$c2018
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000142910 520__ $$aAlthough genome-wide association studies (GWAS) for prostate cancer (PrCa) have identified more than 100 risk regions, most of the risk genes at these regions remain largely unknown. Here we integrate the largest PrCa GWAS (N = 142,392) with gene expression measured in 45 tissues (N = 4458), including normal and tumor prostate, to perform a multi-tissue transcriptome-wide association study (TWAS) for PrCa. We identify 217 genes at 84 independent 1 Mb regions associated with PrCa risk, 9 of which are regions with no genome-wide significant SNP within 2 Mb. 23 genes are significant in TWAS only for alternative splicing models in prostate tumor thus supporting the hypothesis of splicing driving risk for continued oncogenesis. Finally, we use a Bayesian probabilistic approach to estimate credible sets of genes containing the causal gene at a pre-defined level; this reduced the list of 217 associations to 109 genes in the 90% credible set. Overall, our findings highlight the power of integrating expression with PrCa GWAS to identify novel risk loci and prioritize putative causal genes at known risk loci.
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000142910 7001_ $$aGayther, Simon$$b1
000142910 7001_ $$00000-0002-7980-4620$$aGusev, Alexander$$b2
000142910 7001_ $$00000-0003-1226-070X$$aZheng, Wei$$b3
000142910 7001_ $$aPenney, Kathryn L$$b4
000142910 7001_ $$aKote-Jarai, Zsofia$$b5
000142910 7001_ $$00000-0002-3698-6241$$aEeles, Rosalind$$b6
000142910 7001_ $$aFreedman, Matthew$$b7
000142910 7001_ $$aHaiman, Christopher$$b8
000142910 7001_ $$aPasaniuc, Bogdan$$b9
000142910 7001_ $$aconsortium, PRACTICAL$$b10$$eCollaboration Author
000142910 7001_ $$aHenderson, Brian E$$b11
000142910 7001_ $$aBenlloch, Sara$$b12
000142910 7001_ $$aSchumacher, Fredrick R$$b13
000142910 7001_ $$aOlama, Ali Amin Al$$b14
000142910 7001_ $$aMuir, Kenneth$$b15
000142910 7001_ $$aBerndt, Sonja I$$b16
000142910 7001_ $$aConti, David V$$b17
000142910 7001_ $$aWiklund, Fredrik$$b18
000142910 7001_ $$aChanock, Stephen$$b19
000142910 7001_ $$aStevens, Victoria L$$b20
000142910 7001_ $$aTangen, Catherine M$$b21
000142910 7001_ $$aBatra, Jyotsna$$b22
000142910 7001_ $$aClements, Judith$$b23
000142910 7001_ $$aGronberg, Henrik$$b24
000142910 7001_ $$aPashayan, Nora$$b25
000142910 7001_ $$aSchleutker, Johanna$$b26
000142910 7001_ $$aAlbanes, Demetrius$$b27
000142910 7001_ $$aWeinstein, Stephanie$$b28
000142910 7001_ $$aWolk, Alicja$$b29
000142910 7001_ $$aWest, Catharine$$b30
000142910 7001_ $$aMucci, Lorelei$$b31
000142910 7001_ $$aCancel-Tassin, Géraldine$$b32
000142910 7001_ $$aKoutros, Stella$$b33
000142910 7001_ $$aSorensen, Karina Dalsgaard$$b34
000142910 7001_ $$aMaehle, Lovise$$b35
000142910 7001_ $$aNeal, David E$$b36
000142910 7001_ $$aHamdy, Freddie C$$b37
000142910 7001_ $$aDonovan, Jenny L$$b38
000142910 7001_ $$aTravis, Ruth C$$b39
000142910 7001_ $$aHamilton, Robert J$$b40
000142910 7001_ $$aIngles, Sue Ann$$b41
000142910 7001_ $$aRosenstein, Barry$$b42
000142910 7001_ $$aLu, Yong-Jie$$b43
000142910 7001_ $$aGiles, Graham G$$b44
000142910 7001_ $$aKibel, Adam S$$b45
000142910 7001_ $$aVega, Ana$$b46
000142910 7001_ $$aKogevinas, Manolis$$b47
000142910 7001_ $$aPark, Jong Y$$b48
000142910 7001_ $$aStanford, Janet L$$b49
000142910 7001_ $$aCybulski, Cezary$$b50
000142910 7001_ $$aNordestgaard, Børge G$$b51
000142910 7001_ $$0P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2$$aBrenner, Hermann$$b52$$udkfz
000142910 7001_ $$aMaier, Christiane$$b53
000142910 7001_ $$aKim, Jeri$$b54
000142910 7001_ $$aJohn, Esther M$$b55
000142910 7001_ $$aTeixeira, Manuel R$$b56
000142910 7001_ $$aNeuhausen, Susan L$$b57
000142910 7001_ $$aDe Ruyck, Kim$$b58
000142910 7001_ $$aRazack, Azad$$b59
000142910 7001_ $$aNewcomb, Lisa F$$b60
000142910 7001_ $$aLessel, Davor$$b61
000142910 7001_ $$aKaneva, Radka$$b62
000142910 7001_ $$aUsmani, Nawaid$$b63
000142910 7001_ $$aClaessens, Frank$$b64
000142910 7001_ $$aTownsend, Paul A$$b65
000142910 7001_ $$aGago-Dominguez, Manuela$$b66
000142910 7001_ $$aRoobol, Monique J$$b67
000142910 7001_ $$aMenegaux, Florence$$b68
000142910 7001_ $$aKhaw, Kay-Tee$$b69
000142910 7001_ $$aCannon-Albright, Lisa$$b70
000142910 7001_ $$aPandha, Hardev$$b71
000142910 7001_ $$aThibodeau, Stephen N$$b72
000142910 7001_ $$aHunter, David J$$b73
000142910 7001_ $$aKraft, Peter$$b74
000142910 773__ $$0PERI:(DE-600)2553671-0$$a10.1038/s41467-018-06302-1$$gVol. 9, no. 1, p. 4079$$n1$$p4079$$tNature Communications$$v9$$x2041-1723$$y2018
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