TY  - JOUR
AU  - Harris, Rebecca C
AU  - Sumner, Tom
AU  - Knight, Gwenan M
AU  - Evans, Tom
AU  - Cardenas, Vicky
AU  - Chen, Chen
AU  - White, Richard G
TI  - Age-targeted tuberculosis vaccination in China and implications for vaccine development: a modelling study.
JO  - The lancet  / Global health Global health [...]
VL  - 7
IS  - 2
SN  - 2214-109X
CY  - Oxford
PB  - Elsevier
M1  - DKFZ-2019-00542
SP  - e209 - e218
PY  - 2019
AB  - Tuberculosis is the leading single-pathogen cause of death worldwide, and China has the third largest number of cases worldwide. New tools, such as new vaccines, are needed to meet WHO tuberculosis goals. Tuberculosis vaccine development strategies mostly target infants or adolescents, but given China's ageing epidemic, vaccinating older people might be important. We modelled the potential impact of new tuberculosis vaccines in China targeting adolescents (15-19 years) or older adults (60-64 years) with varying vaccine characteristics to inform strategic vaccine development.A Mycobacterium tuberculosis transmission model was calibrated to age-stratified demographic and epidemiological data from China. Varying scenarios of vaccine implementation (age targeting [adolescents or older adults] and coverage [30
LB  - PUB:(DE-HGF)16
C6  - pmid:30630775
DO  - DOI:10.1016/S2214-109X(18)30452-2
UR  - https://inrepo02.dkfz.de/record/142914
ER  -