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000142916 0247_ $$2doi$$a10.1053/j.ajkd.2018.08.013
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000142916 1001_ $$aInker, Lesley A$$b0
000142916 245__ $$aRelationship of Estimated GFR and Albuminuria to Concurrent Laboratory Abnormalities: An Individual Participant Data Meta-analysis in a Global Consortium.
000142916 260__ $$aPhiladelphia, Pa.$$bElsevier Saunders$$c2019
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000142916 520__ $$aChronic kidney disease (CKD) is complicated by abnormalities that reflect disruption in filtration, tubular, and endocrine functions of the kidney. Our aim was to explore the relationship of specific laboratory result abnormalities and hypertension with the estimated glomerular filtration rate (eGFR) and albuminuria CKD staging framework.Cross-sectional individual participant-level analyses in a global consortium.17 CKD and 38 general population and high-risk cohorts.Cohorts in the CKD Prognosis Consortium with data for eGFR and albuminuria, as well as a measurement of hemoglobin, bicarbonate, phosphorus, parathyroid hormone, potassium, or calcium, or hypertension.Data were obtained and analyzed between July 2015 and January 2018.We modeled the association of eGFR and albuminuria with hemoglobin, bicarbonate, phosphorus, parathyroid hormone, potassium, and calcium values using linear regression and with hypertension and categorical definitions of each abnormality using logistic regression. Results were pooled using random-effects meta-analyses.The CKD cohorts (n=254,666 participants) were 27% women and 10% black, with a mean age of 69 (SD, 12) years. The general population/high-risk cohorts (n=1,758,334) were 50% women and 2% black, with a mean age of 50 (16) years. There was a strong graded association between lower eGFR and all laboratory result abnormalities (ORs ranging from 3.27 [95% CI, 2.68-3.97] to 8.91 [95% CI, 7.22-10.99] comparing eGFRs of 15 to 29 with eGFRs of 45 to 59mL/min/1.73m2), whereas albuminuria had equivocal or weak associations with abnormalities (ORs ranging from 0.77 [95% CI, 0.60-0.99] to 1.92 [95% CI, 1.65-2.24] comparing urinary albumin-creatinine ratio > 300 vs < 30mg/g).Variations in study era, health care delivery system, typical diet, and laboratory assays.Lower eGFR was strongly associated with higher odds of multiple laboratory result abnormalities. Knowledge of risk associations might help guide management in the heterogeneous group of patients with CKD.
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000142916 7001_ $$aLevey, Andrew S$$b2
000142916 7001_ $$aCoresh, Josef$$b3
000142916 7001_ $$aCirillo, Massimo$$b4
000142916 7001_ $$aCollins, John F$$b5
000142916 7001_ $$aGansevoort, Ron T$$b6
000142916 7001_ $$aGutierrez, Orlando M$$b7
000142916 7001_ $$aHamano, Takayuki$$b8
000142916 7001_ $$aHeine, Gunnar H$$b9
000142916 7001_ $$aIshikawa, Shizukiyo$$b10
000142916 7001_ $$aJee, Sun Ha$$b11
000142916 7001_ $$aKronenberg, Florian$$b12
000142916 7001_ $$aLandray, Martin J$$b13
000142916 7001_ $$aMiura, Katsuyuki$$b14
000142916 7001_ $$aNadkarni, Girish N$$b15
000142916 7001_ $$aPeralta, Carmen A$$b16
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000142916 7001_ $$aShlipak, Michael G$$b20
000142916 7001_ $$aZhang, Luxia$$b21
000142916 7001_ $$avan Zuilen, Arjan D$$b22
000142916 7001_ $$aHallan, Stein I$$b23
000142916 7001_ $$aKovesdy, Csaba P$$b24
000142916 7001_ $$aWoodward, Mark$$b25
000142916 7001_ $$aLevin, Adeera$$b26
000142916 7001_ $$aConsortium, CKD Prognosis$$b27$$eCollaboration Author
000142916 7001_ $$aAstor, Brad$$b28
000142916 7001_ $$aAppel, Larry$$b29
000142916 7001_ $$aGreene, Tom$$b30
000142916 7001_ $$aChen, Teresa$$b31
000142916 7001_ $$aChalmers, John$$b32
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