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@ARTICLE{Inker:142916,
      author       = {L. A. Inker and M. E. Grams and A. S. Levey and J. Coresh
                      and M. Cirillo and J. F. Collins and R. T. Gansevoort and O.
                      M. Gutierrez and T. Hamano and G. H. Heine and S. Ishikawa
                      and S. H. Jee and F. Kronenberg and M. J. Landray and K.
                      Miura and G. N. Nadkarni and C. A. Peralta and D.
                      Rothenbacher and E. Schaeffner and S. Sedaghat and M. G.
                      Shlipak and L. Zhang and A. D. van Zuilen and S. I. Hallan
                      and C. P. Kovesdy and M. Woodward and A. Levin and B. Astor
                      and L. Appel and T. Greene and T. Chen and J. Chalmers and
                      M. Woodward and H. Arima and V. Perkovic and H. Yatsuya and
                      K. Tamakoshi and Y. Li and Y. Hirakawa and J. Coresh and K.
                      Matsushita and M. Grams and Y. Sang and K. Polkinghorne and
                      S. Chadban and R. Atkins and A. Levin and O. Djurdjev and L.
                      Zhang and L. Liu and M. Zhao and F. Wang and J. Wang and E.
                      Schaeffner and N. Ebert and P. Martus and A. Levin and O.
                      Djurdjev and M. Tang and G. Heine and I. Emrich and S.
                      Seiler and A. Zawada and J. Nally and S. Navaneethan and J.
                      Schold and L. Zhang and M. Zhao and F. Wang and J. Wang and
                      M. Shlipak and M. Sarnak and R. Katz and J. Hiramoto and H.
                      Iso and K. Yamagishi and M. Umesawa and I. Muraki and M.
                      Fukagawa and S. Maruyama and T. Hamano and T. Hasegawa and
                      N. Fujii and D. Wheeler and J. Emberson and J. Townend and
                      M. Landray and H. Brenner$^*$ and B. Schöttker$^*$ and
                      K.-U. Saum$^*$ and D. Rothenbacher$^*$ and C. Fox and S.-J.
                      Hwang and A. Köttgen and F. Kronenberg and M. P. Schneider
                      and K.-U. Eckardt and J. Green and H. L. Kirchner and A. R.
                      Chang and K. Ho and S. Ito and M. Miyazaki and M. Nakayama
                      and G. Yamada and M. Cirillo and F. Irie and T. Sairenchi
                      and S. Ishikawa and Y. Yano and K. Kotani and T. Nakamura
                      and S. H. Jee and H. Kimm and Y. Mok and G. Chodick and V.
                      Shalev and J. F. M. Wetzels and P. J. Blankestijn and A. D.
                      van Zuilen and J. van den Brand and M. Sarnak and L. Inker
                      and C. Peralta and J. Hiramoto and R. Katz and M. Sarnak and
                      F. Kronenberg and B. Kollerits and E. Ritz and D. Nitsch and
                      P. Roderick and A. Fletcher and E. Bottinger and G. N.
                      Nadkarni and S. B. Ellis and R. Nadukuru and Y. Sang and H.
                      Ueshima and A. Okayama and K. Miura and S. Tanaka and H.
                      Ueshima and T. Okamura and K. Miura and S. Tanaka and K.
                      Miura and A. Okayama and A. Kadota and S. Tanaka and T.
                      Kenealy and C. R. Elley and J. F. Collins and P. L. Drury
                      and T. Ohkubo and K. Asayama and H. Metoki and M. Kikuya and
                      M. Nakayama and R. G. Nelson and W. C. Knowler and R. T.
                      Gansevoort and S. J. Bakker and E. Hak and H. J. L.
                      Heerspink and N. Brunskill and R. Major and D. Shepherd and
                      J. Medcalf and S. K. Jassal and J. Bergstrom and J. H. Ix
                      and E. Barrett-Connor and C. Kovesdy and K. Kalantar-Zadeh
                      and K. Sumida and O. M. Gutierrez and P. Muntner and D.
                      Warnock and W. McClellan and H. J. L. Heerspink and D. de
                      Zeeuw and B. Brenner and S. Sedaghat and M. A. Ikram and E.
                      J. Hoorn and A. Dehghan and J. J. Carrero and A. Gasparini
                      and B. Wettermark and C.-G. Elinder and T. Y. Wong and C.
                      Sabanayagam and C.-Y. Cheng and F. L. J. Visseren and M.
                      Evans and M. Segelmark and M. Stendahl and S. Schön and N.
                      Tangri and M. Sud and D. Naimark and C.-P. Wen and C.-K.
                      Tsao and M.-K. Tsai and C.-H. Chen and T. Konta and A.
                      Hirayama and K. Ichikawa and L. Lannfelt and A. Larsson and
                      J. Ärnlöv and H. J. G. Bilo and G. W. D. Landman and K. J.
                      J. van Hateren and N. Kleefstra and J. Coresh Chair and R.
                      T. Gansevoort and M. E. Grams and S. Hallan and C. P.
                      Kovesdy and A. S. Levey and K. Matsushita and V. Shalev and
                      M. Woodward and S. H. Ballew and J. Chen and J. Coresh and
                      M. E. Grams and L. Kwak and K. Matsushita and Y. Sang and A.
                      Surapaneni and M. Woodward},
      collaboration = {C. P. Consortium},
      title        = {{R}elationship of {E}stimated {GFR} and {A}lbuminuria to
                      {C}oncurrent {L}aboratory {A}bnormalities: {A}n {I}ndividual
                      {P}articipant {D}ata {M}eta-analysis in a {G}lobal
                      {C}onsortium.},
      journal      = {American journal of kidney diseases},
      volume       = {73},
      number       = {2},
      issn         = {0272-6386},
      address      = {Philadelphia, Pa.},
      publisher    = {Elsevier Saunders},
      reportid     = {DKFZ-2019-00544},
      pages        = {206 - 217},
      year         = {2019},
      abstract     = {Chronic kidney disease (CKD) is complicated by
                      abnormalities that reflect disruption in filtration,
                      tubular, and endocrine functions of the kidney. Our aim was
                      to explore the relationship of specific laboratory result
                      abnormalities and hypertension with the estimated glomerular
                      filtration rate (eGFR) and albuminuria CKD staging
                      framework.Cross-sectional individual participant-level
                      analyses in a global consortium.17 CKD and 38 general
                      population and high-risk cohorts.Cohorts in the CKD
                      Prognosis Consortium with data for eGFR and albuminuria, as
                      well as a measurement of hemoglobin, bicarbonate,
                      phosphorus, parathyroid hormone, potassium, or calcium, or
                      hypertension.Data were obtained and analyzed between July
                      2015 and January 2018.We modeled the association of eGFR
                      and albuminuria with hemoglobin, bicarbonate, phosphorus,
                      parathyroid hormone, potassium, and calcium values using
                      linear regression and with hypertension and categorical
                      definitions of each abnormality using logistic regression.
                      Results were pooled using random-effects meta-analyses.The
                      CKD cohorts (n=254,666 participants) were $27\%$ women and
                      $10\%$ black, with a mean age of 69 (SD, 12) years. The
                      general population/high-risk cohorts (n=1,758,334) were
                      $50\%$ women and $2\%$ black, with a mean age of 50 (16)
                      years. There was a strong graded association between lower
                      eGFR and all laboratory result abnormalities (ORs ranging
                      from 3.27 $[95\%$ CI, 2.68-3.97] to 8.91 $[95\%$ CI,
                      7.22-10.99] comparing eGFRs of 15 to 29 with eGFRs of 45 to
                      59mL/min/1.73m2), whereas albuminuria had equivocal or weak
                      associations with abnormalities (ORs ranging from 0.77
                      $[95\%$ CI, 0.60-0.99] to 1.92 $[95\%$ CI, 1.65-2.24]
                      comparing urinary albumin-creatinine ratio > 300 vs <
                      30mg/g).Variations in study era, health care delivery
                      system, typical diet, and laboratory assays.Lower eGFR was
                      strongly associated with higher odds of multiple laboratory
                      result abnormalities. Knowledge of risk associations might
                      help guide management in the heterogeneous group of patients
                      with CKD.},
      cin          = {C070},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30348535},
      pmc          = {pmc:PMC6348050},
      doi          = {10.1053/j.ajkd.2018.08.013},
      url          = {https://inrepo02.dkfz.de/record/142916},
}