000142926 001__ 142926
000142926 005__ 20240229112535.0
000142926 0247_ $$2doi$$a10.1158/0008-5472.CAN-17-3864
000142926 0247_ $$2pmid$$apmid:30487138
000142926 0247_ $$2pmc$$apmc:PMC6359979
000142926 0247_ $$2ISSN$$a0008-5472
000142926 0247_ $$2ISSN$$a0099-7013
000142926 0247_ $$2ISSN$$a0099-7374
000142926 0247_ $$2ISSN$$a1538-7445
000142926 0247_ $$2altmetric$$aaltmetric:52010131
000142926 037__ $$aDKFZ-2019-00554
000142926 041__ $$aeng
000142926 082__ $$a610
000142926 1001_ $$aBuckley, Melissa A$$b0
000142926 245__ $$aFunctional Analysis and Fine Mapping of the 9p22.2 Ovarian Cancer Susceptibility Locus.
000142926 260__ $$aPhiladelphia, Pa.$$bAACR$$c2019
000142926 3367_ $$2DRIVER$$aarticle
000142926 3367_ $$2DataCite$$aOutput Types/Journal article
000142926 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1634722043_16360
000142926 3367_ $$2BibTeX$$aARTICLE
000142926 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000142926 3367_ $$00$$2EndNote$$aJournal Article
000142926 520__ $$a: Genome-wide association studies have identified 40 ovarian cancer risk loci. However, the mechanisms underlying these associations remain elusive. In this study, we conducted a two-pronged approach to identify candidate causal SNPs and assess underlying biological mechanisms at chromosome 9p22.2, the first and most statistically significant associated locus for ovarian cancer susceptibility. Three transcriptional regulatory elements with allele-specific effects and a scaffold/matrix attachment region were characterized and, through physical DNA interactions, BNC2 was established as the most likely target gene. We determined the consensus binding sequence for BNC2 in vitro, verified its enrichment in BNC2 ChIP-seq regions, and validated a set of its downstream target genes. Fine-mapping by dense regional genotyping in over 15,000 ovarian cancer cases and 30,000 controls identified SNPs in the scaffold/matrix attachment region as among the most likely causal variants. This study reveals a comprehensive regulatory landscape at 9p22.2 and proposes a likely mechanism of susceptibility to ovarian cancer. SIGNIFICANCE: Mapping the 9p22.2 ovarian cancer risk locus identifies BNC2 as an ovarian cancer risk gene.See related commentary by Choi and Brown, p. 439.
000142926 536__ $$0G:(DE-HGF)POF3-313$$a313 - Cancer risk factors and prevention (POF3-313)$$cPOF3-313$$fPOF III$$x0
000142926 588__ $$aDataset connected to CrossRef, PubMed,
000142926 7001_ $$aWoods, Nicholas T$$b1
000142926 7001_ $$aTyrer, Jonathan P$$b2
000142926 7001_ $$aMendoza-Fandiño, Gustavo$$b3
000142926 7001_ $$00000-0002-6469-2515$$aLawrenson, Kate$$b4
000142926 7001_ $$00000-0003-0749-9935$$aHazelett, Dennis J$$b5
000142926 7001_ $$00000-0003-2735-4231$$aNajafabadi, Hamed S$$b6
000142926 7001_ $$aGjyshi, Anxhela$$b7
000142926 7001_ $$aCarvalho, Renato S$$b8
000142926 7001_ $$aLyra, Paulo C$$b9
000142926 7001_ $$00000-0003-4267-5930$$aCoetzee, Simon G$$b10
000142926 7001_ $$aShen, Howard C$$b11
000142926 7001_ $$aYang, Ally W$$b12
000142926 7001_ $$aEarp, Madalene A$$b13
000142926 7001_ $$00000-0003-0005-7798$$aYoder, Sean J$$b14
000142926 7001_ $$aRisch, Harvey$$b15
000142926 7001_ $$aChenevix-Trench, Georgia$$b16
000142926 7001_ $$aRamus, Susan J$$b17
000142926 7001_ $$aPhelan, Catherine M$$b18
000142926 7001_ $$00000-0003-4267-5930$$aCoetzee, Gerhard A$$b19
000142926 7001_ $$00000-0003-4051-8114$$aNoushmehr, Houtan$$b20
000142926 7001_ $$aHughes, Timothy R$$b21
000142926 7001_ $$aSellers, Thomas A$$b22
000142926 7001_ $$aGoode, Ellen L$$b23
000142926 7001_ $$aPharoah, Paul D$$b24
000142926 7001_ $$aGayther, Simon A$$b25
000142926 7001_ $$aMonteiro, Alvaro N A$$b26
000142926 7001_ $$aConsortium, Ovarian Cancer Association$$b27$$eCollaboration Author
000142926 7001_ $$0P:(DE-He78)3c7f9136fb168ffb766316ea4ca1a58b$$aRudolph, Anja$$b28
000142926 7001_ $$0P:(DE-He78)c259d6cc99edf5c7bc7ce22c7f87c253$$aChang-Claude, Jenny$$b29
000142926 773__ $$0PERI:(DE-600)2036785-5$$a10.1158/0008-5472.CAN-17-3864$$gVol. 79, no. 3, p. 467 - 481$$n3$$p467 - 481$$tCancer research$$v79$$x1538-7445$$y2019
000142926 909CO $$ooai:inrepo02.dkfz.de:142926$$pVDB
000142926 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)3c7f9136fb168ffb766316ea4ca1a58b$$aDeutsches Krebsforschungszentrum$$b28$$kDKFZ
000142926 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)c259d6cc99edf5c7bc7ce22c7f87c253$$aDeutsches Krebsforschungszentrum$$b29$$kDKFZ
000142926 9131_ $$0G:(DE-HGF)POF3-313$$1G:(DE-HGF)POF3-310$$2G:(DE-HGF)POF3-300$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lKrebsforschung$$vCancer risk factors and prevention$$x0
000142926 9141_ $$y2019
000142926 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline
000142926 915__ $$0StatID:(DE-HGF)0310$$2StatID$$aDBCoverage$$bNCBI Molecular Biology Database
000142926 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bCANCER RES : 2017
000142926 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS
000142926 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search
000142926 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC
000142926 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List
000142926 915__ $$0StatID:(DE-HGF)0110$$2StatID$$aWoS$$bScience Citation Index
000142926 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection
000142926 915__ $$0StatID:(DE-HGF)0111$$2StatID$$aWoS$$bScience Citation Index Expanded
000142926 915__ $$0StatID:(DE-HGF)1110$$2StatID$$aDBCoverage$$bCurrent Contents - Clinical Medicine
000142926 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences
000142926 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews
000142926 915__ $$0StatID:(DE-HGF)9905$$2StatID$$aIF >= 5$$bCANCER RES : 2017
000142926 9201_ $$0I:(DE-He78)C020-20160331$$kC020$$lC020 Epidemiologie von Krebs$$x0
000142926 980__ $$ajournal
000142926 980__ $$aVDB
000142926 980__ $$aI:(DE-He78)C020-20160331
000142926 980__ $$aUNRESTRICTED