TY  - JOUR
AU  - Gao, Xin
AU  - Zhang, Yan
AU  - Burwinkel, Barbara
AU  - Xuan, Yang
AU  - Holleczek, Bernd
AU  - Brenner, Hermann
AU  - Schöttker, Ben
TI  - The associations of DNA methylation alterations in oxidative stress-related genes with cancer incidence and mortality outcomes: a population-based cohort study.
JO  - Clinical epigenetics
VL  - 11
IS  - 1
SN  - 1868-7083
CY  - [S.l.]
PB  - BioMed Central
M1  - DKFZ-2019-00561
SP  - 14
PY  - 2019
AB  - Reactive oxygen species may be involved in epigenetic gene activation or silencing. We aimed to identify CpG sites, at which DNA methylation is related to urinary 8-isoprostane levels (biomarker of lipid peroxidation) and cancer or mortality outcomes. This investigation was based on a German, population-based cohort with linkage to cancer and mortality registry data (2000-2016).Blood DNA methylation in promoter regions of 519 genes, known to be involved in pathways from oxidative stress (OS) to cancer, was obtained at the cohort's baseline examination. Inverse associations of DNA methylation at cg25365794 (ALOXE3) and cg08862778 (MTOR) with 8-isoprostane levels were observed in a derivation set (n = 1000) and validated in two independent subsets of the cohort (n = 548 and n = 741). Multivariate regression models were used to evaluate the associations of DNA methylation at the two CpG sites with lung, colorectal, prostate, breast, and overall cancer incidence as well as CVD, cancer, and all-cause mortality. DNA methylation at cg25365794 (ALOXE3) was inversely associated with lung and prostate cancer incidence. DNA methylation at cg08862778 (MTOR) was associated with a 43
LB  - PUB:(DE-HGF)16
C6  - pmid:30678711
C2  - pmc:PMC6346508
DO  - DOI:10.1186/s13148-018-0604-y
UR  - https://inrepo02.dkfz.de/record/142933
ER  -