TY  - JOUR
AU  - Gies, Anton
AU  - Cuk, Katarina
AU  - Schrotz-King, Petra
AU  - Brenner, Hermann
TI  - Combination of Different Fecal Immunochemical Tests in Colorectal Cancer Screening: Any Gain in Diagnostic Performance?
JO  - Cancers
VL  - 11
IS  - 1
SN  - 2072-6694
CY  - Basel
PB  - MDPI
M1  - DKFZ-2019-00562
SP  - 120
PY  - 2019
AB  - A variety of fecal immunochemical tests (FITs) are used for colorectal cancer screening. FIT performance could be improved further. It is unclear, whether the combination of different FITs with different analytical characteristics (such as, different antibodies for the detection of fecal hemoglobin) can yield a better diagnostic performance. Fecal samples were obtained from 2042 participants of screening colonoscopy. All participants with advanced neoplasm (AN, colorectal cancer (n = 16) or advanced adenoma (n = 200)) and 300 randomly selected participants without AN were included. Nine quantitative FITs were evaluated simultaneously. Sensitivity and specificity was calculated for single tests (n = 9) and for their pairwise test combinations (n = 36) (requiring either both FITs (P++) or at least one FIT (P+) to be positive for defining a positive test result). Mean age of the participants (n = 516) was 63 (range: 50⁻79) years and 56
LB  - PUB:(DE-HGF)16
C6  - pmid:30669538
C2  - pmc:PMC6356298
DO  - DOI:10.3390/cancers11010120
UR  - https://inrepo02.dkfz.de/record/142934
ER  -