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@ARTICLE{Logan:142941,
      author       = {C. A. Logan and J. M. Weiss and W. Koenig and B. Stahl and
                      P. Carr$^*$ and H. Brenner$^*$ and D. Rothenbacher and J.
                      Genuneit},
      title        = {{S}oluble {CD}14 concentration in human breast milk and its
                      potential role in child atopic dermatitis: {R}esults of the
                      {U}lm {B}irth {C}ohort {S}tudies.},
      journal      = {Clinical $\&$ experimental allergy},
      volume       = {49},
      number       = {2},
      issn         = {0954-7894},
      address      = {Oxford},
      publisher    = {Blackwell52631},
      reportid     = {DKFZ-2019-00569},
      pages        = {199-206},
      year         = {2019},
      abstract     = {Soluble CD14 (sCD14) is one of many factors in human breast
                      milk which may influence programming of the immune response
                      in the breastfed child. Although previous studies have
                      mostly found little association between sCD14 concentration
                      in breast milk and atopic outcomes, recent evidence
                      continues to support a role of sCD14 in immune-related
                      disease.We aimed to clarify whether an association exists
                      between sCD14 concentration in human breast milk (m-sCD14)
                      and child atopic dermatitis (AD) diagnosis by age 3 years
                      within the context of two large birth cohorts.Data were
                      obtained from the Ulm Birth Cohort Study (UBCS) and the Ulm
                      SPATZ Health Study, methodologically similar birth cohort
                      studies, each consisting of approximately 1000 newborns and
                      their mothers recruited from the general population shortly
                      after delivery in Ulm, Southern Germany, respectively, from
                      11/2000 to 11/2001 and 04/2012 to 05/2013. sCD14
                      concentrations were measured by different ELISAs (UBCS: IBL,
                      SPATZ: $R\&D)$ in breast milk samples collected at 6 weeks
                      post-delivery in both studies and additionally at 6 months
                      and 1 year in SPATZ. Children's AD diagnosis was assessed
                      using parent and paediatrician reports at 1, 2 and 3 years
                      of age.Complete exposure and outcome data were available for
                      659 UBCS and 489 SPATZ children. In both cohorts, sCD14
                      concentration was significantly associated with
                      breastfeeding frequency (P < 0.01). We observed no
                      association between m-sCD14 concentration and child AD
                      diagnosis in either study.Our results do not support an
                      association between sCD14 concentration in mature breast
                      milk and AD among breastfed children.},
      cin          = {C070},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30084516},
      doi          = {10.1111/cea.13245},
      url          = {https://inrepo02.dkfz.de/record/142941},
}