TY  - JOUR
AU  - Eschke, Robert-Christopher Karl-Richard
AU  - Lampit, Amit
AU  - Schenk, Alexander
AU  - Javelle, Florian
AU  - Steindorf, Karen
AU  - Diel, Patrick
AU  - Bloch, Wilhelm
AU  - Zimmer, Philipp
TI  - Impact of Physical Exercise on Growth and Progression of Cancer in Rodents-A Systematic Review and Meta-Analysis.
JO  - Frontiers in oncology
VL  - 9
SN  - 2234-943X
CY  - Lausanne
PB  - Frontiers Media
M1  - DKFZ-2019-00577
SP  - 35
PY  - 2019
AB  - Background: Physical exercise is suspected to reduce cancer risk and mortality. So far, little is known about the underlying mechanisms. Although limited, murine models represent a promising attempt in order to gain knowledge in this field. Objective: A systematic review and meta-analysis examining various treatment protocols was conducted in order to determine the impact of exercise on tumor growth in rodents. Methods: PubMed, Google scholar and System for information on Gray literature in Europe were screened from inception to October 2017. Risk of bias within individual studies was assessed using the Office of Health Assessment and Translation risk of bias rating tool for human and animal trials. The effect of exercise on tumor growth over and above non-exercise control was pooled using random-effects model. Subgroup analyses were conducted to identify potential moderators. Results: The quality of the included 17 articles ranged between 'probably low' and 'high risk of bias.' A significant reduction in tumor growth in exercising animals compared to controls was detected (Hedges' g = -0.40; 95
LB  - PUB:(DE-HGF)16
C6  - pmid:30805305
C2  - pmc:PMC6370688
DO  - DOI:10.3389/fonc.2019.00035
UR  - https://inrepo02.dkfz.de/record/142949
ER  -