%0 Journal Article
%A Leeksma, Alexander C
%A Taylor, Justin
%A Wu, Bian
%A Gardner, Jeffrey R
%A He, Jie
%A Nahas, Michelle
%A Gonen, Mithat
%A Alemayehu, Wendimagegn G
%A Te Raa, Doreen
%A Walther, Tatjana
%A Hüllein, Jennifer
%A Dietrich, Sascha
%A Claus, Rainer
%A de Boer, Fransien
%A de Heer, Koen
%A Dubois, Julie
%A Dampmann, Maria
%A Dürig, Jan
%A van Oers, Marinus H J
%A Geisler, Christian H
%A Eldering, Eric
%A Levine, Ross L
%A Miller, Vincent
%A Mughal, Tariq
%A Lamanna, Nicole
%A Frattini, Mark G
%A Heaney, Mark L
%A Zelenetz, Andrew
%A Zenz, Thorsten
%A Abdel-Wahab, Omar
%A Kater, Arnon P
%T Clonal diversity predicts adverse outcome in chronic lymphocytic leukemia.
%J Leukemia
%V 33
%N 2
%@ 1476-5551
%C London
%I Springer Nature
%M DKFZ-2019-00590
%P 390 - 402
%D 2019
%X Genomic analyses of chronic lymphocytic leukemia (CLL) identified somatic mutations and associations of clonal diversity with adverse outcomes. Clonal evolution likely has therapeutic implications but its dynamic is less well studied. We studied clonal composition and prognostic value of seven recurrently mutated driver genes using targeted next-generation sequencing in 643 CLL patients and found higher frequencies of mutations in TP53 (35 vs. 12
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:30038380
%R 10.1038/s41375-018-0215-9
%U https://inrepo02.dkfz.de/record/142962