TY  - JOUR
AU  - Leeksma, Alexander C
AU  - Taylor, Justin
AU  - Wu, Bian
AU  - Gardner, Jeffrey R
AU  - He, Jie
AU  - Nahas, Michelle
AU  - Gonen, Mithat
AU  - Alemayehu, Wendimagegn G
AU  - Te Raa, Doreen
AU  - Walther, Tatjana
AU  - Hüllein, Jennifer
AU  - Dietrich, Sascha
AU  - Claus, Rainer
AU  - de Boer, Fransien
AU  - de Heer, Koen
AU  - Dubois, Julie
AU  - Dampmann, Maria
AU  - Dürig, Jan
AU  - van Oers, Marinus H J
AU  - Geisler, Christian H
AU  - Eldering, Eric
AU  - Levine, Ross L
AU  - Miller, Vincent
AU  - Mughal, Tariq
AU  - Lamanna, Nicole
AU  - Frattini, Mark G
AU  - Heaney, Mark L
AU  - Zelenetz, Andrew
AU  - Zenz, Thorsten
AU  - Abdel-Wahab, Omar
AU  - Kater, Arnon P
TI  - Clonal diversity predicts adverse outcome in chronic lymphocytic leukemia.
JO  - Leukemia
VL  - 33
IS  - 2
SN  - 1476-5551
CY  - London
PB  - Springer Nature
M1  - DKFZ-2019-00590
SP  - 390 - 402
PY  - 2019
AB  - Genomic analyses of chronic lymphocytic leukemia (CLL) identified somatic mutations and associations of clonal diversity with adverse outcomes. Clonal evolution likely has therapeutic implications but its dynamic is less well studied. We studied clonal composition and prognostic value of seven recurrently mutated driver genes using targeted next-generation sequencing in 643 CLL patients and found higher frequencies of mutations in TP53 (35 vs. 12
LB  - PUB:(DE-HGF)16
C6  - pmid:30038380
DO  - DOI:10.1038/s41375-018-0215-9
UR  - https://inrepo02.dkfz.de/record/142962
ER  -