TY  - JOUR
AU  - Graf, Robin
AU  - Seagal, Jane
AU  - Otipoby, Kevin L
AU  - Lam, Kong-Peng
AU  - Ayoub, Salah
AU  - Zhang, Baochun
AU  - Sander, Sandrine
AU  - Chu, Van Trung
AU  - Rajewsky, Klaus
TI  - BCR-dependent lineage plasticity in mature B cells.
JO  - Science
VL  - 363
IS  - 6428
SN  - 0036-8075
CY  - Cambridge, Mass.
PB  - Moses King
M1  - DKFZ-2019-00612
SP  - 748 - 753
PY  - 2019
AB  - B2 cells engage in classical antibody responses, whereas B1 cells are considered carriers of innate immunity, biased toward recognizing epitopes present on the surfaces of common pathogens and self antigens. To explore the role of B cell antigen receptor (BCR) specificity in driving B1 cell differentiation, we developed a transgenic system allowing us to change BCR specificity in B cells in an inducible and programmed manner. Mature B2 cells differentiated into bona fide B1 cells upon acquisition of a B1 cell-typical self-reactive BCR through a phase of proliferative expansion. Thus, B2 cells have B1 cell differentiation potential in addition to their classical capacity to differentiate into memory and plasma cells, and B1 differentiation can be instructed by BCR-mediated self-reactivity, in the absence of B1-lineage precommitment.
LB  - PUB:(DE-HGF)16
C6  - pmid:30765568
DO  - DOI:10.1126/science.aau8475
UR  - https://inrepo02.dkfz.de/record/142984
ER  -