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@ARTICLE{Graf:142984,
      author       = {R. Graf and J. Seagal and K. L. Otipoby and K.-P. Lam and
                      S. Ayoub and B. Zhang and S. Sander$^*$ and V. T. Chu and K.
                      Rajewsky},
      title        = {{BCR}-dependent lineage plasticity in mature {B} cells.},
      journal      = {Science},
      volume       = {363},
      number       = {6428},
      issn         = {0036-8075},
      address      = {Cambridge, Mass.},
      publisher    = {Moses King},
      reportid     = {DKFZ-2019-00612},
      pages        = {748 - 753},
      year         = {2019},
      abstract     = {B2 cells engage in classical antibody responses, whereas B1
                      cells are considered carriers of innate immunity, biased
                      toward recognizing epitopes present on the surfaces of
                      common pathogens and self antigens. To explore the role of B
                      cell antigen receptor (BCR) specificity in driving B1 cell
                      differentiation, we developed a transgenic system allowing
                      us to change BCR specificity in B cells in an inducible and
                      programmed manner. Mature B2 cells differentiated into bona
                      fide B1 cells upon acquisition of a B1 cell-typical
                      self-reactive BCR through a phase of proliferative
                      expansion. Thus, B2 cells have B1 cell differentiation
                      potential in addition to their classical capacity to
                      differentiate into memory and plasma cells, and B1
                      differentiation can be instructed by BCR-mediated
                      self-reactivity, in the absence of B1-lineage
                      precommitment.},
      cin          = {D180},
      ddc          = {500},
      cid          = {I:(DE-He78)D180-20160331},
      pnm          = {314 - Tumor immunology (POF3-314)},
      pid          = {G:(DE-HGF)POF3-314},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30765568},
      doi          = {10.1126/science.aau8475},
      url          = {https://inrepo02.dkfz.de/record/142984},
}