%0 Journal Article
%A Kar, Siddhartha P
%A Andrulis, Irene L
%A Brenner, Hermann
%A Burgess, Stephen
%A Chang-Claude, Jenny
%A Considine, Daniel
%A Dörk, Thilo
%A Evans, Dafydd Gareth R
%A Gago-Domínguez, Manuela
%A Giles, Graham G
%A Hartman, Mikael
%A Huo, Dezheng
%A Kaaks, Rudolf
%A Li, Jingmei
%A Lophatananon, Artitaya
%A Margolin, Sara
%A Milne, Roger L
%A Muir, Kenneth R
%A Olsson, Håkan
%A Punie, Kevin
%A Radice, Paolo
%A Simard, Jacques
%A Tamimi, Rulla M
%A Van Nieuwenhuysen, Els
%A Wendt, Camilla
%A Zheng, Wei
%A Pharoah, Paul D P
%T The association between weight at birth and breast cancer risk revisited using Mendelian randomisation.
%J European journal of epidemiology
%V 34
%N 6
%@ 1573-7284
%C Dordrecht [u.a.]
%I Springer Science + Business Media B.V.
%M DKFZ-2019-00624
%P 591-600
%D 2019
%X Observational studies suggest that higher birth weight (BW) is associated with increased risk of breast cancer in adult life. We conducted a two-sample Mendelian randomisation (MR) study to assess whether this association is causal. Sixty independent single nucleotide polymorphisms (SNPs) known to be associated at P < 5 × 10-8 with BW were used to construct (1) a 41-SNP instrumental variable (IV) for univariable MR after removing SNPs with pleiotropic associations with other breast cancer risk factors and (2) a 49-SNP IV for multivariable MR after filtering SNPs for data availability. BW predicted by the 41-SNP IV was not associated with overall breast cancer risk in inverse-variance weighted (IVW) univariable MR analysis of genetic association data from 122,977 breast cancer cases and 105,974 controls (odds ratio = 0.86 per 500 g higher BW; 95
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:30737679
%R 10.1007/s10654-019-00485-7
%U https://inrepo02.dkfz.de/record/142999