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000142999 1001_ $$00000-0002-2314-1426$$aKar, Siddhartha P$$b0
000142999 245__ $$aThe association between weight at birth and breast cancer risk revisited using Mendelian randomisation.
000142999 260__ $$aDordrecht [u.a.]$$bSpringer Science + Business Media B.V.$$c2019
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000142999 520__ $$aObservational studies suggest that higher birth weight (BW) is associated with increased risk of breast cancer in adult life. We conducted a two-sample Mendelian randomisation (MR) study to assess whether this association is causal. Sixty independent single nucleotide polymorphisms (SNPs) known to be associated at P < 5 × 10-8 with BW were used to construct (1) a 41-SNP instrumental variable (IV) for univariable MR after removing SNPs with pleiotropic associations with other breast cancer risk factors and (2) a 49-SNP IV for multivariable MR after filtering SNPs for data availability. BW predicted by the 41-SNP IV was not associated with overall breast cancer risk in inverse-variance weighted (IVW) univariable MR analysis of genetic association data from 122,977 breast cancer cases and 105,974 controls (odds ratio = 0.86 per 500 g higher BW; 95% confidence interval 0.73-1.01). Sensitivity analyses using four alternative methods and three alternative IVs, including an IV with 59 of the 60 BW-associated SNPs, yielded similar results. Multivariable MR adjusting for the effects of the 49-SNP IV on birth length, adult height, adult body mass index, age at menarche, and age at menopause using IVW and MR-Egger methods provided estimates consistent with univariable analyses. Results were also similar when all analyses were repeated after restricting to estrogen receptor-positive or -negative breast cancer cases. Point estimates of the odds ratios from most analyses performed indicated an inverse relationship between genetically-predicted BW and breast cancer, but we are unable to rule out an association between the non-genetically-determined component of BW and breast cancer. Thus, genetically-predicted higher BW was not associated with an increased risk of breast cancer in adult life in our MR study.
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000142999 7001_ $$aAndrulis, Irene L$$b1
000142999 7001_ $$0P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2$$aBrenner, Hermann$$b2$$udkfz
000142999 7001_ $$aBurgess, Stephen$$b3
000142999 7001_ $$0P:(DE-He78)c259d6cc99edf5c7bc7ce22c7f87c253$$aChang-Claude, Jenny$$b4$$udkfz
000142999 7001_ $$aConsidine, Daniel$$b5
000142999 7001_ $$aDörk, Thilo$$b6
000142999 7001_ $$aEvans, Dafydd Gareth R$$b7
000142999 7001_ $$aGago-Domínguez, Manuela$$b8
000142999 7001_ $$aGiles, Graham G$$b9
000142999 7001_ $$aHartman, Mikael$$b10
000142999 7001_ $$aHuo, Dezheng$$b11
000142999 7001_ $$0P:(DE-He78)4b2dc91c9d1ac33a1c0e0777d0c1697a$$aKaaks, Rudolf$$b12$$udkfz
000142999 7001_ $$aLi, Jingmei$$b13
000142999 7001_ $$aLophatananon, Artitaya$$b14
000142999 7001_ $$aMargolin, Sara$$b15
000142999 7001_ $$aMilne, Roger L$$b16
000142999 7001_ $$aMuir, Kenneth R$$b17
000142999 7001_ $$aOlsson, Håkan$$b18
000142999 7001_ $$aPunie, Kevin$$b19
000142999 7001_ $$aRadice, Paolo$$b20
000142999 7001_ $$aSimard, Jacques$$b21
000142999 7001_ $$aTamimi, Rulla M$$b22
000142999 7001_ $$aVan Nieuwenhuysen, Els$$b23
000142999 7001_ $$aWendt, Camilla$$b24
000142999 7001_ $$aZheng, Wei$$b25
000142999 7001_ $$aPharoah, Paul D P$$b26
000142999 773__ $$0PERI:(DE-600)2004992-4$$a10.1007/s10654-019-00485-7$$n6$$p591-600$$tEuropean journal of epidemiology$$v34$$x1573-7284$$y2019
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