TY  - JOUR
AU  - Kar, Siddhartha P
AU  - Andrulis, Irene L
AU  - Brenner, Hermann
AU  - Burgess, Stephen
AU  - Chang-Claude, Jenny
AU  - Considine, Daniel
AU  - Dörk, Thilo
AU  - Evans, Dafydd Gareth R
AU  - Gago-Domínguez, Manuela
AU  - Giles, Graham G
AU  - Hartman, Mikael
AU  - Huo, Dezheng
AU  - Kaaks, Rudolf
AU  - Li, Jingmei
AU  - Lophatananon, Artitaya
AU  - Margolin, Sara
AU  - Milne, Roger L
AU  - Muir, Kenneth R
AU  - Olsson, Håkan
AU  - Punie, Kevin
AU  - Radice, Paolo
AU  - Simard, Jacques
AU  - Tamimi, Rulla M
AU  - Van Nieuwenhuysen, Els
AU  - Wendt, Camilla
AU  - Zheng, Wei
AU  - Pharoah, Paul D P
TI  - The association between weight at birth and breast cancer risk revisited using Mendelian randomisation.
JO  - European journal of epidemiology
VL  - 34
IS  - 6
SN  - 1573-7284
CY  - Dordrecht [u.a.]
PB  - Springer Science + Business Media B.V.
M1  - DKFZ-2019-00624
SP  - 591-600
PY  - 2019
AB  - Observational studies suggest that higher birth weight (BW) is associated with increased risk of breast cancer in adult life. We conducted a two-sample Mendelian randomisation (MR) study to assess whether this association is causal. Sixty independent single nucleotide polymorphisms (SNPs) known to be associated at P < 5 × 10-8 with BW were used to construct (1) a 41-SNP instrumental variable (IV) for univariable MR after removing SNPs with pleiotropic associations with other breast cancer risk factors and (2) a 49-SNP IV for multivariable MR after filtering SNPs for data availability. BW predicted by the 41-SNP IV was not associated with overall breast cancer risk in inverse-variance weighted (IVW) univariable MR analysis of genetic association data from 122,977 breast cancer cases and 105,974 controls (odds ratio = 0.86 per 500 g higher BW; 95
LB  - PUB:(DE-HGF)16
C6  - pmid:30737679
DO  - DOI:10.1007/s10654-019-00485-7
UR  - https://inrepo02.dkfz.de/record/142999
ER  -