%0 Journal Article
%A Rahbari, Nuh N
%A Carr, Prudence
%A Jansen, Lina
%A Chang-Claude, Jenny
%A Weitz, Jürgen
%A Hoffmeister, Michael
%A Brenner, Hermann
%T Time of Metastasis and Outcome in Colorectal Cancer.
%J Annals of surgery
%V 269
%N 3
%@ 0003-4932
%C [S.l.]
%I Ovid38850
%M DKFZ-2019-00629
%P 494 - 502
%D 2019
%X The aim of this study was to evaluate outcomes of metastases at various time intervals after colorectal cancer (CRC) diagnosis.Earlier studies have indicated a short time interval between CRC diagnosis and distant metastases to be associated with poor prognosis. The majority of studies assessed outcome from CRC diagnosis or metastasis resection rather than from metastasis diagnosis and might be subject to immortal time bias.Patients in the population-based DACHS study were stratified: metastases at/within 1 month (immediate), 2 to 6 months (early), 7 to 12 months (intermediate), and >12 months (late) after CRC diagnosis. The primary endpoint was overall survival (OS) from metastasis diagnosis. Cox proportional hazards regression models were used to calculate hazard ratios (HRs) and 95
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:29064893
%R 10.1097/SLA.0000000000002564
%U https://inrepo02.dkfz.de/record/143004