%0 Journal Article
%A Gao, Xu
%A Gào, Xīn
%A Zhang, Yan
%A Holleczek, Bernd
%A Schöttker, Ben
%A Brenner, Hermann
%T Oxidative stress and epigenetic mortality risk score: associations with all-cause mortality among elderly people.
%J European journal of epidemiology
%V 34
%N 5
%@ 1573-7284
%C Dordrecht [u.a.]
%I Springer Science + Business Media B.V.
%M DKFZ-2019-00631
%P 451-462
%D 2019
%X Oxidative stress (OS) has been found to be related to accelerated aging and many aging-related health outcomes. Recently, an epigenetic 'mortality risk score' (MS) based on whole blood DNA methylation at 10 mortality-related CpG sites has been demonstrated to be associated with all-cause mortality. This study aimed to address the association between OS and MS, and to assess and compare their performance in the prediction of all-cause mortality. For 1448 participants aged 50-75 of the German ESTHER cohort study, the MS was derived from the DNA methylation profiles measured by Illumina HumanMethylation450K Beadchip and the levels of two urinary OS markers, 8-isoprostane (8-iso) and oxidized guanine/guanosine [including 8-hydroxy-2'-deoxyguanosine (8-oxo)], were measured by ELISA kits. Associations between OS markers and the MS were evaluated by linear and ordinal logistic regression models, and their associations with all-cause mortality were examined by Cox regression models. Both OS markers were associated with the MS at baseline. The 8-iso levels and MS, but not 8-oxo levels, were associated with all-cause mortality during a median follow-up of 15.1 years. Fully-adjusted hazard ratios (95
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:30771035
%R 10.1007/s10654-019-00493-7
%U https://inrepo02.dkfz.de/record/143006