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@ARTICLE{Gao:143006,
      author       = {X. Gao$^*$ and X. Gào$^*$ and Y. Zhang$^*$ and B.
                      Holleczek and B. Schöttker$^*$ and H. Brenner$^*$},
      title        = {{O}xidative stress and epigenetic mortality risk score:
                      associations with all-cause mortality among elderly people.},
      journal      = {European journal of epidemiology},
      volume       = {34},
      number       = {5},
      issn         = {1573-7284},
      address      = {Dordrecht [u.a.]},
      publisher    = {Springer Science + Business Media B.V.},
      reportid     = {DKFZ-2019-00631},
      pages        = {451-462},
      year         = {2019},
      abstract     = {Oxidative stress (OS) has been found to be related to
                      accelerated aging and many aging-related health outcomes.
                      Recently, an epigenetic 'mortality risk score' (MS) based on
                      whole blood DNA methylation at 10 mortality-related CpG
                      sites has been demonstrated to be associated with all-cause
                      mortality. This study aimed to address the association
                      between OS and MS, and to assess and compare their
                      performance in the prediction of all-cause mortality. For
                      1448 participants aged 50-75 of the German ESTHER cohort
                      study, the MS was derived from the DNA methylation profiles
                      measured by Illumina HumanMethylation450K Beadchip and the
                      levels of two urinary OS markers, 8-isoprostane (8-iso) and
                      oxidized guanine/guanosine [including
                      8-hydroxy-2'-deoxyguanosine (8-oxo)], were measured by ELISA
                      kits. Associations between OS markers and the MS were
                      evaluated by linear and ordinal logistic regression models,
                      and their associations with all-cause mortality were
                      examined by Cox regression models. Both OS markers were
                      associated with the MS at baseline. The 8-iso levels and MS,
                      but not 8-oxo levels, were associated with all-cause
                      mortality during a median follow-up of 15.1 years.
                      Fully-adjusted hazard ratios $(95\%$ CI) were 1.56
                      (1.13-2.16) for the 4th quartile of 8-iso levels compared
                      with the 1st, 1.71 (1.27-2.29) and 2.92 (2.03-4.18) for the
                      moderate and high MS defined by 2-5 and > 5 CpG sites with
                      aberrant methylation compared with a MS of 0-1,
                      respectively. After controlling for 8-iso levels, the hazard
                      ratios of MS remained essentially unchanged while the
                      association of 8-iso levels with mortality was attenuated.
                      This study demonstrates that OS is highly associated with
                      the epigenetic MS, and the latter at the same time has a
                      higher predictive value for all-cause mortality.},
      cin          = {C070 / L101},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331 / I:(DE-He78)L101-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30771035},
      doi          = {10.1007/s10654-019-00493-7},
      url          = {https://inrepo02.dkfz.de/record/143006},
}