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@ARTICLE{Doege:143008,
      author       = {D. Doege$^*$ and M. Thong$^*$ and L. Koch-Gallenkamp$^*$
                      and H. Bertram and A. Eberle and B. Holleczek and R.
                      Pritzkuleit and M. Waldeyer-Sauerland and A. Waldmann and S.
                      R. Zeissig and L. Jansen$^*$ and H. Brenner$^*$ and V.
                      Arndt$^*$},
      title        = {{H}ealth-related quality of life in long-term disease-free
                      breast cancer survivors versus female population controls in
                      {G}ermany.},
      journal      = {Breast cancer research and treatment},
      volume       = {175},
      number       = {2},
      issn         = {1573-7217},
      address      = {Dordrecht [u.a.]},
      publisher    = {Springer Science + Business Media B.V.},
      reportid     = {DKFZ-2019-00633},
      pages        = {499-510},
      year         = {2019},
      abstract     = {Little is known about breast cancer (BC) survivors'
                      health-related quality of life (HRQoL) > 5 or even
                      > 10 years past diagnosis. It is of interest whether, in
                      the long run, survivors' HRQoL aligns with that of the
                      general population. Study objectives were to (1) compare
                      disease-free BC survivors' HRQoL to that of non-cancer
                      controls, and (2) compare long-term survivors (LTS,
                      5-9 years post-diagnosis), very long-term survivors (VLTS,
                      ≥ 10 years post-diagnosis), and controls with respect
                      to their HRQoL.The samples of 2647 disease-free BC survivors
                      (5-16 years post-diagnosis) and 1005 population controls
                      were recruited in German multi-regional population-based
                      studies. HRQoL was assessed by the European Organization for
                      Research and Treatment of Cancer Quality of Life
                      Questionnaire-Core 30 (EORTC QLQ-C30). Differences in HRQoL
                      were assessed with multiple regression, controlling for age
                      and education.Disease-free BC survivors < 80 years (at
                      survey) reported overall global health status/quality of
                      life comparable to controls, but statistically significant
                      lower physical, role, emotional, social, and cognitive
                      functioning. They also indicated more fatigue, insomnia,
                      dyspnoea, and financial difficulties. However, differences
                      were only of trivial or small clinical relevance. At age
                      80-89, no differences between BC survivors and controls were
                      observed. Deficits in emotional and cognitive functioning
                      and some symptoms (e.g. insomnia and fatigue) persist, as
                      both LTS and VLTS reported more detriments than controls.In
                      view of the persistent, small but significant detriments in
                      disease-free BC survivors' cognitive and emotional
                      functioning and higher symptom burden, possibilities to
                      prevent detriments from becoming chronic should be
                      explored.},
      cin          = {C071 / C070 / C120},
      ddc          = {610},
      cid          = {I:(DE-He78)C071-20160331 / I:(DE-He78)C070-20160331 /
                      I:(DE-He78)C120-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30826935},
      doi          = {10.1007/s10549-019-05188-x},
      url          = {https://inrepo02.dkfz.de/record/143008},
}