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@ARTICLE{Kriegsmann:143012,
      author       = {K. Kriegsmann and M.-A. Baertsch and M. H. S. Awwad and M.
                      Merz and D. Hose and A. Seckinger and A. Jauch and N.
                      Becker$^*$ and A. Benner$^*$ and M. S. Raab and J.
                      Hillengass and U. Bertsch and J. Dürig and H. J. Salwender
                      and M. Hänel and R. Fenk and M. Munder and K. Weisel and C.
                      Müller-Tidow and H. Goldschmidt and M. Hundemer},
      title        = {{C}ereblon-binding proteins expression levels correlate
                      with hyperdiploidy in newly diagnosed multiple myeloma
                      patients.},
      journal      = {Blood cancer journal},
      volume       = {9},
      number       = {2},
      issn         = {2044-5385},
      address      = {London [u.a.]},
      publisher    = {Nature Publishing Group},
      reportid     = {DKFZ-2019-00637},
      pages        = {13},
      year         = {2019},
      abstract     = {Immunomodulatory drugs (IMIDs) are very effective in the
                      treatment of multiple myeloma (MM). The description of their
                      cereblon-mediated mechanism of action was a hallmark in MM
                      research. Although the importance of IMID-induced
                      degradation of cereblon-binding proteins is well described
                      in vitro, the prognostic value of their expression levels in
                      MM cells is less clear. Based on recently published data
                      showing somewhat conflicting RNA levels, we analyzed the
                      association between the levels of the Ikaros family zinc
                      finger protein 1 (IKZF1), IKZF3, and karyopherin subunit
                      alpha 2 (KPNA2) proteins measured by flow cytometry and
                      prognostic parameters in 214 newly diagnosed MM patients who
                      were randomized in the GMMG HD6 trial. No statistically
                      significant associations between the expression levels and
                      age, gender, light chain type, International Staging System
                      (ISS) stage or cytogenetic high- and normal risk groups
                      could be identified. Hyperdiploid MM cells expressed
                      significantly higher levels of IKZF1, IKZF3 and KPNA2 than
                      nonhyperdiploid cells. In contrast, translocation t(11;14)
                      was associated with significantly lower expression levels.
                      In conclusion, the observed overexpression of
                      cereblon-binding proteins in MM cells with gain of
                      chromosomes 5, 9, 11, 15, and 19 is consistent with the
                      previously proposed positive regulation of MYC by IKZF1 and
                      IKZF3, as well as MYC activation in hyperdiploid MM cells.},
      cin          = {C060},
      ddc          = {610},
      cid          = {I:(DE-He78)C060-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30696815},
      pmc          = {pmc:PMC6351644},
      doi          = {10.1038/s41408-019-0174-z},
      url          = {https://inrepo02.dkfz.de/record/143012},
}