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@ARTICLE{Bhl:143033,
      author       = {L. Bühl and T. Abel and F. Wolf and M. Oberste and W.
                      Bloch and M. Hallek and T. Elter and P. Zimmer$^*$},
      title        = {{F}easibility and {P}otential {B}enefits of an {E}xercise
                      {I}ntervention in a {M}ale {W}ith {D}own {S}yndrome
                      {U}ndergoing {H}igh-{D}ose {C}hemotherapy for {A}cute
                      {L}ymphoblastic {L}eukemia: {A} {C}ase {R}eport.},
      journal      = {Integrative cancer therapies},
      volume       = {18},
      issn         = {1552-695X},
      address      = {Thousand Oaks, Calif.},
      publisher    = {Sage},
      reportid     = {DKFZ-2019-00652},
      pages        = {153473541983235 -},
      year         = {2019},
      abstract     = {In patients with hematological malignancies, exercise is
                      studied as a supportive measure with potential benefits on
                      therapy and disease-related side effects. However, clinical
                      trials have not yet integrated people with Down syndrome
                      (DS), although this disability is associated with an
                      increased risk for hematological malignancies. Therefore, we
                      examined safety and feasibility of a mixed-modality exercise
                      intervention in a male with DS undergoing high-dose
                      chemotherapy for acute lymphoblastic leukemia. Furthermore,
                      physical capacity and fatigue were assessed. Exercise
                      sessions took place 3 times/wk over a 5-week period.
                      Adherence to the exercise program was $100\%,$ and no
                      serious adverse events occurred. In contrast to the training
                      sessions, applied endurance testing was not feasible.
                      Furthermore, maintenance of fatigue level was observed. In
                      conclusion, cancer patients with DS suffering from leukemia
                      should not be excluded from physical activity or exercise
                      programs.},
      cin          = {C110},
      ddc          = {610},
      cid          = {I:(DE-He78)C110-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30795696},
      doi          = {10.1177/1534735419832358},
      url          = {https://inrepo02.dkfz.de/record/143033},
}