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@ARTICLE{Gregson:143040,
      author       = {J. Gregson and S. Kaptoge and T. Bolton and L. Pennells and
                      P. Willeit and S. Burgess and S. Bell and M. Sweeting and E.
                      B. Rimm and C. Kabrhel and B. Zöller and G. Assmann and V.
                      Gudnason and A. R. Folsom and V. Arndt$^*$ and A. Fletcher
                      and P. E. Norman and B. G. Nordestgaard and A. Kitamura and
                      B. K. Mahmoodi and P. H. Whincup and M. Knuiman and V.
                      Salomaa and C. Meisinger and W. Koenig and M. Kavousi and H.
                      Völzke and J. A. Cooper and T. Ninomiya and E. Casiglia and
                      B. Rodriguez and Y. Ben-Shlomo and J.-P. Després and L.
                      Simons and E. Barrett-Connor and C. Björkelund and M.
                      Notdurfter and D. Kromhout and J. Price and S. E. Sutherland
                      and J. Sundström and J. Kauhanen and J. Gallacher and J. W.
                      J. Beulens and R. Dankner and C. Cooper and S. Giampaoli and
                      J. F. Deen and A. Gómez de la Cámara and L. H. Kuller and
                      A. Rosengren and P. J. Svensson and D. Nagel and C. J.
                      Crespo and H. Brenner and J. R. Albertorio-Diaz and R.
                      Atkins and E. J. Brunner and M. Shipley and I. Njølstad and
                      D. A. Lawlor and Y. T. van der Schouw and R. M. Selmer and
                      M. Trevisan and W. M. M. Verschuren and P. Greenland and S.
                      Wassertheil-Smoller and G. D. O. Lowe and A. M. Wood and A.
                      S. Butterworth and S. G. Thompson and J. Danesh and E. Di
                      Angelantonio and T. Meade and W. Rosamond and E. Whitsel and
                      M. Cushman and E. L. Barr and J. E. Shaw and P. Z. Zimmet
                      and M. Knuiman and P. H. Whincup and S. Kiechl and S. Weger
                      and J. Willeit and D. A. Lawlor and A. Amuzu and C. Dale and
                      J. P. Casas and J. Gallacher and V. Tikhonoff and P.
                      Greenland and P. Nietert and A. Tybjærg-Hansen and R.
                      Frikke-Schmidt and G. B. Jensen and D. L. Pablos and P. C.
                      Navia and L. Simons and S. McLachlan and B. Schöttker$^*$
                      and K.-U. Saum$^*$ and B. Holleczek and I. Ariansen and H.
                      E. Meyer and L. L. Håheim and E. Vartiainen and P.
                      Jousilahti and K. Harald and R. Dankner and A. Rosengren and
                      L. Wilhelmsen and C. Björkelund and D. Nagel and E.
                      Dennison and H. Syddall and L. Westbury and L. Flicker and
                      G. J. Hankey and J. Golledge and T. Ninomiya and Y. Doi and
                      Y. Kiyohara and B. Rodriguez and P. Elders and C. Stehouwer
                      and C. Kabrhel and M. Jensen and A. Kitamura and H. Iso and
                      K. Yamagishi and V. Salomaa and K. Sudhir and T.-P.
                      Tuomainen and J. T. Salonen and J. A. Cooper and J. M. A.
                      Boer and A. Blokstra and O. Melander and P. M. Nilsson and
                      G. Engström and M. Trevisan and L. Palmieri and D. Vanuzzo
                      and S. Giampaoli and A. Peters and B. Thorand and M. Heier
                      and A. Fletcher and L. H. Kuller and J. R. Albertorio-Diaz
                      and E. B. Rimm and F. B. Hu and J. E. Manson and K. Meijer
                      and R. T. Gansevoort and C. J. Crespo and G. Assmann and H.
                      Schulte and I. Sluijs and B. Cantin and B. Lamarche and G.
                      R. Dagenais and L. McEvoy and G. Laughlin and L. B. Daniels
                      and T. Aspelund and E. F. Gudmundsson and B. Thorsson and M.
                      J. G. Leening and M. A. Ikram and O. H. Franco and H.
                      Tunstall-Pedoe and H. Völzke and A. Werner and R. Devereux
                      and S. Jolly and G. D. Smith and G. Can and H. Yüksel and
                      S. Altay and I. Njølstad and M. Ingelsson and V. Giedraitis
                      and H. Brenner$^*$ and H. Claessen and D. Rothenbacher and
                      N. I. Parikh and C. Eaton and M. Shipley and M. Kivimaki and
                      E. J. Brunner and E. Feskens and J. M. Geleijnse and D.
                      Kromhout and T. Bolton and S. Spackman and M. Walker and T.
                      Bolton and S. Burgess and A. S. Butterworth and E. Di
                      Angelantonio and S. Kaptoge and L. Pennells and S. Spackman
                      and S. G. Thompson and M. Walker and A. M. Wood and J.
                      Danesh},
      collaboration = {Emerging Risk {Factors Collaboration}},
      title        = {{C}ardiovascular {R}isk {F}actors {A}ssociated {W}ith
                      {V}enous {T}hromboembolism.},
      journal      = {JAMA cardiology},
      volume       = {4},
      number       = {2},
      issn         = {2380-6583},
      address      = {Chicago, Ill.},
      publisher    = {American Medical Association},
      reportid     = {DKFZ-2019-00659},
      pages        = {163 -173},
      year         = {2019},
      abstract     = {It is uncertain to what extent established cardiovascular
                      risk factors are associated with venous thromboembolism
                      (VTE).To estimate the associations of major cardiovascular
                      risk factors with VTE, ie, deep vein thrombosis and
                      pulmonary embolism.This study included individual
                      participant data mostly from essentially population-based
                      cohort studies from the Emerging Risk Factors Collaboration
                      (ERFC; 731 728 participants; 75 cohorts; years of baseline
                      surveys, February 1960 to June 2008; latest date of
                      follow-up, December 2015) and the UK Biobank (421 537
                      participants; years of baseline surveys, March 2006 to
                      September 2010; latest date of follow-up, February 2016).
                      Participants without cardiovascular disease at baseline were
                      included. Data were analyzed from June 2017 to September
                      2018.A panel of several established cardiovascular risk
                      factors.Hazard ratios (HRs) per 1-SD higher usual risk
                      factor levels (or presence/absence). Incident fatal outcomes
                      in ERFC (VTE, 1041; coronary heart disease [CHD],
                      25 131) and incident fatal/nonfatal outcomes in UK Biobank
                      (VTE, 2321; CHD, 3385). Hazard ratios were adjusted for age,
                      sex, smoking status, diabetes, and body mass index (BMI).Of
                      the 731 728 participants from the ERFC, 403 396
                      $(55.1\%)$ were female, and the mean (SD) age at the time of
                      the survey was 51.9 (9.0) years; of the 421 537
                      participants from the UK Biobank, 233 699 $(55.4\%)$ were
                      female, and the mean (SD) age at the time of the survey was
                      56.4 (8.1) years. Risk factors for VTE included older age
                      (ERFC: HR per decade, 2.67; $95\%$ CI, 2.45-2.91; UK
                      Biobank: HR, 1.81; $95\%$ CI, 1.71-1.92), current smoking
                      (ERFC: HR, 1.38; $95\%$ CI, 1.20-1.58; UK Biobank: HR, 1.23;
                      $95\%$ CI, 1.08-1.40), and BMI (ERFC: HR per 1-SD higher
                      BMI, 1.43; $95\%$ CI, 1.35-1.50; UK Biobank: HR, 1.37;
                      $95\%$ CI, 1.32-1.41). For these factors, there were similar
                      HRs for pulmonary embolism and deep vein thrombosis in UK
                      Biobank (except adiposity was more strongly associated with
                      pulmonary embolism) and similar HRs for unprovoked vs
                      provoked VTE. Apart from adiposity, these risk factors were
                      less strongly associated with VTE than CHD. There were
                      inconsistent associations of VTEs with diabetes and blood
                      pressure across ERFC and UK Biobank, and there was limited
                      ability to study lipid and inflammation markers.Older age,
                      smoking, and adiposity were consistently associated with
                      higher VTE risk.},
      cin          = {C070 / C120},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331 / I:(DE-He78)C120-20160331},
      pnm          = {323 - Metabolic Dysfunction as Risk Factor (POF3-323)},
      pid          = {G:(DE-HGF)POF3-323},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30649175},
      pmc          = {pmc:PMC6386140},
      doi          = {10.1001/jamacardio.2018.4537},
      url          = {https://inrepo02.dkfz.de/record/143040},
}