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000143049 1001_ $$0P:(DE-He78)8d9c904a6cea14d4c99c78ba46e41f93$$aKorshunov, Andrey$$b0$$eFirst author$$udkfz
000143049 245__ $$aIntegrated molecular characterization of IDH-mutant glioblastomas.
000143049 260__ $$aOxford [u.a.]$$bWiley-Blackwell$$c2019
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000143049 520__ $$aMutations of isocitrate dehydrogenase (IDH)1/2 affect almost all astrocytomas of WHO grade II and III. A subset of IDH-mutant astrocytic tumours progresses to IDH-mutant glioblastoma or presents with the histology of a glioblastoma at first presentation. We set out here to assess the molecular spectrum of IDH-mutant glioblastomas.We performed an integrated molecular analysis of a mono-centric cohort (n = 97); assessed through genome-wide DNA methylation analysis, copy-number profiling and targeted next generation sequencing using a neurooncology-tailored gene panel.Of these 97 IDH-mutant glioblastomas, 68 had a glioblastoma at first presentation (de novo IDH-mutant glioblastoma) and 29 emerged from a prior low-grade lesion (evolved IDH-mutant glioblastoma). Unsupervised hierarchical clustering of DNA methylation data disclosed that IDH-mutant glioblastoma (de novo and evolved) formed a distinct group separate from other diffuse glioma subtypes. Homozygous deletions of CDKN2A/B were found to be associated with shorter survival.This study demonstrates DNA methylation patterns in IDH-mutant glioblastoma to be distinct from lower-grade astrocytic counterparts but homogeneous within de novo and evolved IDH-mutant glioblastomas, and identifies CDKN2A as a marker for possible genetic sub-stratification.
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000143049 7001_ $$0P:(DE-HGF)0$$aCasalini, B.$$b1
000143049 7001_ $$0P:(DE-He78)082dd3179733e3e716a58eb90f418a78$$aChavez, L.$$b2$$udkfz
000143049 7001_ $$0P:(DE-He78)743a4a82daab55306a2c88b9f6bf8c2f$$aHielscher, T.$$b3$$udkfz
000143049 7001_ $$0P:(DE-He78)45440b44791309bd4b7dbb4f73333f9b$$aSill, M.$$b4$$udkfz
000143049 7001_ $$aRyzhova, M.$$b5
000143049 7001_ $$0P:(DE-He78)36e1ec4777d5b7887344177dca41eae9$$aSharma, T.$$b6$$udkfz
000143049 7001_ $$0P:(DE-He78)e54a1e0999c1d8c95869ef9188b794cc$$aSchrimpf, D.$$b7$$udkfz
000143049 7001_ $$0P:(DE-He78)d20d08adc992abdb6ccffa1686f1ba17$$aStichel, D.$$b8$$udkfz
000143049 7001_ $$0P:(DE-He78)51bf9ae9cb5771b30c483e5597ef606c$$aCapper, D.$$b9$$udkfz
000143049 7001_ $$0P:(DE-HGF)0$$aReuss, D. E.$$b10
000143049 7001_ $$0P:(DE-He78)a46a5b2a871859c8e2d63d2f8c666807$$aSturm, D.$$b11$$udkfz
000143049 7001_ $$aAbsalyamova, O.$$b12
000143049 7001_ $$aGolanov, A.$$b13
000143049 7001_ $$0P:(DE-He78)b84967c4f073b71405404f3719c788cd$$aLambo, S.$$b14$$udkfz
000143049 7001_ $$0P:(DE-He78)7999346780553d7fab7ba69d5afdfa71$$aBewerunge-Hudler, M.$$b15$$udkfz
000143049 7001_ $$0P:(DE-He78)e13b4363c5fe858044ef8a39c02c870c$$aLichter, P.$$b16$$udkfz
000143049 7001_ $$aHerold-Mende, C.$$b17
000143049 7001_ $$0P:(DE-He78)92e9783ca7025f36ce14e12cd348d2ee$$aWick, W.$$b18$$udkfz
000143049 7001_ $$0P:(DE-He78)f746aa965c4e1af518b016de3aaff5d9$$aPfister, Stefan$$b19$$udkfz
000143049 7001_ $$0P:(DE-He78)4c28e2aade5f44d8eca9dd8e97638ec8$$aKool, M.$$b20$$udkfz
000143049 7001_ $$0P:(DE-He78)551bb92841f634070997aa168d818492$$aJones, David$$b21$$udkfz
000143049 7001_ $$0P:(DE-He78)a8a10626a848d31e70cfd96a133cc144$$avon Deimling, A.$$b22$$udkfz
000143049 7001_ $$0P:(DE-He78)a1f4b408b9155beb2a8f7cba4d04fe88$$aSahm, Felix$$b23$$eLast author$$udkfz
000143049 773__ $$0PERI:(DE-600)2008293-9$$a10.1111/nan.12523$$gVol. 45, no. 2, p. 108 - 118$$n2$$p108 - 118$$tNeuropathology & applied neurobiology$$v45$$x0305-1846$$y2019
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