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| 001 | 143049 | ||
| 005 | 20240229112541.0 | ||
| 024 | 7 | _ | |a 10.1111/nan.12523 |2 doi |
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| 041 | _ | _ | |a eng |
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| 100 | 1 | _ | |a Korshunov, Andrey |0 P:(DE-He78)8d9c904a6cea14d4c99c78ba46e41f93 |b 0 |e First author |u dkfz |
| 245 | _ | _ | |a Integrated molecular characterization of IDH-mutant glioblastomas. |
| 260 | _ | _ | |a Oxford [u.a.] |c 2019 |b Wiley-Blackwell |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1555404231_10187 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
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| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Mutations of isocitrate dehydrogenase (IDH)1/2 affect almost all astrocytomas of WHO grade II and III. A subset of IDH-mutant astrocytic tumours progresses to IDH-mutant glioblastoma or presents with the histology of a glioblastoma at first presentation. We set out here to assess the molecular spectrum of IDH-mutant glioblastomas.We performed an integrated molecular analysis of a mono-centric cohort (n = 97); assessed through genome-wide DNA methylation analysis, copy-number profiling and targeted next generation sequencing using a neurooncology-tailored gene panel.Of these 97 IDH-mutant glioblastomas, 68 had a glioblastoma at first presentation (de novo IDH-mutant glioblastoma) and 29 emerged from a prior low-grade lesion (evolved IDH-mutant glioblastoma). Unsupervised hierarchical clustering of DNA methylation data disclosed that IDH-mutant glioblastoma (de novo and evolved) formed a distinct group separate from other diffuse glioma subtypes. Homozygous deletions of CDKN2A/B were found to be associated with shorter survival.This study demonstrates DNA methylation patterns in IDH-mutant glioblastoma to be distinct from lower-grade astrocytic counterparts but homogeneous within de novo and evolved IDH-mutant glioblastomas, and identifies CDKN2A as a marker for possible genetic sub-stratification. |
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| 700 | 1 | _ | |a Golanov, A. |b 13 |
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| 700 | 1 | _ | |a Jones, David |0 P:(DE-He78)551bb92841f634070997aa168d818492 |b 21 |u dkfz |
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| 700 | 1 | _ | |a Sahm, Felix |0 P:(DE-He78)a1f4b408b9155beb2a8f7cba4d04fe88 |b 23 |e Last author |u dkfz |
| 773 | _ | _ | |a 10.1111/nan.12523 |g Vol. 45, no. 2, p. 108 - 118 |0 PERI:(DE-600)2008293-9 |n 2 |p 108 - 118 |t Neuropathology & applied neurobiology |v 45 |y 2019 |x 0305-1846 |
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