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@ARTICLE{Pfaehler:143057,
      author       = {E. Pfaehler and A. Zwanenburg and J. R. de Jong and R.
                      Boellaard},
      title        = {{R}a{C}a{T}: {A}n open source and easy to use radiomics
                      calculator tool.301},
      journal      = {PLOS ONE},
      volume       = {14},
      number       = {2},
      issn         = {1932-6203},
      address      = {San Francisco, California, US},
      publisher    = {PLOS},
      reportid     = {DKFZ-2019-00676},
      pages        = {e0212223 -},
      year         = {2019},
      abstract     = {The widely known field Radiomics aims to provide an
                      extensive image based phenotyping of e.g. tumors using a
                      wide variety of feature values extracted from medical
                      images. Therefore, it is of utmost importance that feature
                      values calculated by different institutes follow the same
                      feature definitions. For this purpose, the imaging biomarker
                      standardization initiative (IBSI) provides detailed
                      mathematical feature descriptions, as well as (mathematical)
                      test phantoms and corresponding reference feature values. We
                      present here an easy to use radiomic feature calculator,
                      RaCaT, which provides the calculation of a large number of
                      radiomic features for all kind of medical images which are
                      in compliance with the standard.The calculator is
                      implemented in C++ and comes as a standalone executable.
                      Therefore, it can be easily integrated in any programming
                      language, but can also be called from the command line. No
                      programming skills are required to use the calculator. The
                      software architecture is highly modularized so that it is
                      easily extendible. The user can also download the source
                      code, adapt it if needed and build the calculator from
                      source. The calculated feature values are compliant with the
                      ones provided by the IBSI standard. Source code, example
                      files for the software configuration, and documentation can
                      be found online on GitHub
                      (https://github.com/ellipfaehlerUMCG/RaCat).The comparison
                      with the standard values shows that all calculated features
                      as well as image preprocessing steps, comply with the IBSI
                      standard. The performance is also demonstrated on clinical
                      examples.The authors successfully implemented an easy to use
                      Radiomics calculator that can be called from any programming
                      language or from the command line. Image preprocessing and
                      feature settings and calculations can be adjusted by the
                      user.},
      cin          = {L301 / G947},
      ddc          = {610},
      cid          = {I:(DE-He78)L301-20160331 / I:(DE-He78)G947-20160331},
      pnm          = {899 - ohne Topic (POF3-899) / 317 - Translational cancer
                      research (POF3-317)},
      pid          = {G:(DE-HGF)POF3-899 / G:(DE-HGF)POF3-317},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30785937},
      pmc          = {pmc:PMC6382170},
      doi          = {10.1371/journal.pone.0212223},
      url          = {https://inrepo02.dkfz.de/record/143057},
}