TY  - JOUR
AU  - Schlenk, Richard
AU  - Weber, Daniela
AU  - Fiedler, Walter
AU  - Salih, Helmut R
AU  - Wulf, Gerald
AU  - Salwender, Hans
AU  - Schroeder, Thomas
AU  - Kindler, Thomas
AU  - Lübbert, Michael
AU  - Wolf, Dominik
AU  - Westermann, Jörg
AU  - Kraemer, Doris
AU  - Götze, Katharina S
AU  - Horst, Heinz-August
AU  - Krauter, Jürgen
AU  - Girschikofsky, Michael
AU  - Ringhoffer, Mark
AU  - Südhoff, Thomas
AU  - Held, Gerhard
AU  - Derigs, Hans-Günter
AU  - Schroers, Roland
AU  - Greil, Richard
AU  - Grießhammer, Martin
AU  - Lange, Elisabeth
AU  - Burchardt, Alexander
AU  - Martens, Uwe
AU  - Hertenstein, Bernd
AU  - Marretta, Lore
AU  - Heuser, Michael
AU  - Thol, Felicitas
AU  - Gaidzik, Verena I
AU  - Herr, Wolfgang
AU  - Krzykalla, Julia
AU  - Benner, Axel
AU  - Döhner, Konstanze
AU  - Ganser, Arnold
AU  - Paschka, Peter
AU  - Döhner, Hartmut
TI  - Midostaurin added to chemotherapy and continued single-agent maintenance therapy in acute myeloid leukemia with FLT3-ITD.
JO  - Blood
VL  - 133
IS  - 8
SN  - 0006-4971
CY  - Stanford, Calif.
PB  - HighWire Press
M1  - DKFZ-2019-00681
SP  - 840 - 851
PY  - 2019
AB  - Patients with acute myeloid leukemia (AML) and a FLT3 internal tandem duplication (ITD) have poor outcomes to current treatment. A phase 2 hypothesis-generating trial was conducted to determine whether the addition of the multitargeted kinase inhibitor midostaurin to intensive chemotherapy followed by allogeneic hematopoietic cell transplantation (alloHCT) and single-agent maintenance therapy of 12 months is feasible and favorably influences event-free survival (EFS) compared with historical controls. Patients 18 to 70 years of age with newly diagnosed AML and centrally confirmed FLT3-ITD were eligible: 284 patients were treated, including 198 younger (18-60 years) and 86 older (61-70 years) patients. Complete remission (CR) rate, including CR with incomplete hematological recovery (CRi) after induction therapy, was 76.4
LB  - PUB:(DE-HGF)16
C6  - pmid:30563875
DO  - DOI:10.1182/blood-2018-08-869453
UR  - https://inrepo02.dkfz.de/record/143062
ER  -