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| Home > Publications database > WHO 2016 classification: changes and advancements in the diagnosis of miscellaneous primary CNS tumours. > print |
| 001 | 143136 | ||
| 005 | 20240229105153.0 | ||
| 024 | 7 | _ | |a 10.1111/nan.12397 |2 doi |
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| 100 | 1 | _ | |a Sahm, Felix |0 P:(DE-He78)a1f4b408b9155beb2a8f7cba4d04fe88 |b 0 |e First author |u dkfz |
| 245 | _ | _ | |a WHO 2016 classification: changes and advancements in the diagnosis of miscellaneous primary CNS tumours. |
| 260 | _ | _ | |a Oxford [u.a.] |c 2018 |b Wiley-Blackwell |
| 336 | 7 | _ | |a article |2 DRIVER |
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| 520 | _ | _ | |a This short review highlights significant changes and recent findings incorporated to varying extent in the WHO 2016 definition of a variety of tumours, including peripheral nerve sheath tumours, meningiomas, mesenchymal nonmeningothelial tumours, melanocytic tumours, lymphomas and histiocytic tumours, germ cell tumours and non-neuroendocrine pituitary tumours. Most notable classification changes include: adding hybrid nerve sheath tumours to the spectrum of benign nerve sheath tumours; an updated definition of atypical meningioma (WHO grade II), including cases with brain invasion; recognizing dural solitary fibrous tumour (SFT) and haemangiopericytoma (HPC) as a single tumour entity characterized by NAB2 and STAT6 gene fusions for which the term SFT/HPC was chosen; recognizing that pituitary granular cell tumour, spindle cell oncocytoma, and pituicytoma all share nuclear expression of TTF-1, possibly representing a spectrum of a single nosological entity derived from posterior pituitary glial cells. The most significant diagnostic markers which have emerged include: inactivation of NF1, CDKN2A, and PRC2 components, SUZ12 and EED in MPNST, leading to neurofibromin and H3K27me3 expression loss; GNAQ and GNA11 mutations in CNS primary melanocytic tumours; BRAFV600E mutation in histiocytic tumours (Langerhans cell histiocytosis and Erdheim-Chester disease) and papillary craniopharyngioma, which provides both a diagnostic marker in the appropriate pathological setting and a therapeutic target. The WHO 2016 Classification has balanced cutting-edge knowledge on the molecular characteristics of the miscellaneous CNS tumours reviewed here with a practical approach for their daily diagnostic work-up. Much more progress can be expected in the classification of these neoplasms in the near future. |
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| 700 | 1 | _ | |a Reuss, D. E. |0 P:(DE-HGF)0 |b 1 |
| 700 | 1 | _ | |a Giannini, C. |b 2 |
| 773 | _ | _ | |a 10.1111/nan.12397 |g Vol. 44, no. 2, p. 163 - 171 |0 PERI:(DE-600)2008293-9 |n 2 |p 163 - 171 |t Neuropathology & applied neurobiology |v 44 |y 2018 |x 0305-1846 |
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