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024 7 _ |a 10.1038/s41598-019-41449-x
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037 _ _ |a DKFZ-2019-00766
041 _ _ |a eng
082 _ _ |a 600
100 1 _ |a Hellmuth, Christian
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245 _ _ |a An individual participant data meta-analysis on metabolomics profiles for obesity and insulin resistance in European children.
260 _ _ |a [London]
|c 2019
|b Macmillan Publishers Limited, part of Springer Nature
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520 _ _ |a Childhood obesity prevalence is rising in countries worldwide. A variety of etiologic factors contribute to childhood obesity but little is known about underlying biochemical mechanisms. We performed an individual participant meta-analysis including 1,020 pre-pubertal children from three European studies and investigated the associations of 285 metabolites measured by LC/MS-MS with BMI z-score, height, weight, HOMA, and lipoprotein concentrations. Seventeen metabolites were significantly associated with BMI z-score. Sphingomyelin (SM) 32:2 showed the strongest association with BMI z-score (P = 4.68 × 10-23) and was also closely related to weight, and less strongly to height and LDL, but not to HOMA. Mass spectrometric analyses identified SM 32:2 as myristic acid containing SM d18:2/14:0. Thirty-five metabolites were significantly associated to HOMA index. Alanine showed the strongest positive association with HOMA (P = 9.77 × 10-16), while acylcarnitines and non-esterified fatty acids were negatively associated with HOMA. SM d18:2/14:0 is a powerful marker for molecular changes in childhood obesity. Tracing back the origin of SM 32:2 to dietary source in combination with genetic predisposition will path the way for early intervention programs. Metabolic profiling might facilitate risk prediction and personalized interventions in overweight children.
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700 1 _ |a Kirchberg, Franca F
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700 1 _ |a Brandt, Stephanie
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700 1 _ |a Moß, Anja
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700 1 _ |a Walter, Viola
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700 1 _ |a Rothenbacher, Dietrich
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700 1 _ |a Brenner, Hermann
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700 1 _ |a Grote, Veit
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700 1 _ |a Gruszfeld, Dariusz
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700 1 _ |a Socha, Piotr
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700 1 _ |a Closa-Monasterolo, Ricardo
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700 1 _ |a Escribano, Joaquin
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700 1 _ |a Luque, Veronica
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700 1 _ |a Verduci, Elvira
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700 1 _ |a Mariani, Benedetta
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700 1 _ |a Langhendries, Jean-Paul
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700 1 _ |a Poncelet, Pascale
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700 1 _ |a Heinrich, Joachim
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700 1 _ |a Lehmann, Irina
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700 1 _ |a Standl, Marie
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700 1 _ |a Uhl, Olaf
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700 1 _ |a Koletzko, Berthold
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700 1 _ |a Thiering, Elisabeth
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700 1 _ |a Wabitsch, Martin
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773 _ _ |a 10.1038/s41598-019-41449-x
|g Vol. 9, no. 1, p. 5053
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|t Scientific reports
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