%0 Journal Article
%A Balavarca Villanueva, Yesilda
%A Weigl, Korbinian
%A Thomsen, Hauke
%A Brenner, Hermann
%T Performance of individual and joint risk stratification by an environmental risk score and a genetic risk score in a colorectal cancer screening setting.
%J International journal of cancer
%V 146
%N 3
%@ 1097-0215
%C Bognor Regis
%I Wiley-Liss
%M DKFZ-2019-00768
%P 627-634
%D 2020
%Z 2020 Feb 1;146(3):627-634#EA:C120#LA:C120#
%X Early detection of colorectal neoplasms can reduce the disease burden of colorectal cancer by timely intervention of individuals at high risk. Our aim was to evaluate a joint environmental-genetic risk score as a risk stratification tool for early detection of advanced colorectal neoplasm (ACRN). Known environmental risk factors and high-risk genetic loci were summarized into risk scores for ACRN in 1014 eligible participants of a screening study. The performances of single and joint environmental-genetic scores were evaluated with estimates and 95
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:30868574
%R 10.1002/ijc.32272
%U https://inrepo02.dkfz.de/record/143169