000143170 001__ 143170
000143170 005__ 20240229112542.0
000143170 0247_ $$2doi$$a10.1016/j.cgh.2019.03.001
000143170 0247_ $$2pmid$$apmid:30851476
000143170 0247_ $$2ISSN$$a1542-3565
000143170 0247_ $$2ISSN$$a1542-7714
000143170 037__ $$aDKFZ-2019-00769
000143170 041__ $$aeng
000143170 082__ $$a610
000143170 1001_ $$0P:(DE-He78)6d4d6a0e2d726f899086ca98cd560922$$aGies, Anton$$b0$$eFirst author$$udkfz
000143170 245__ $$aEffect of Imperfect Compliance With Instructions for Fecal Sample Collection on Diagnostic Performance of 9 Fecal Immunochemical Tests.
000143170 260__ $$aNew York, NY$$bElsevier Science$$c2019
000143170 3367_ $$2DRIVER$$aarticle
000143170 3367_ $$2DataCite$$aOutput Types/Journal article
000143170 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1573738542_29982
000143170 3367_ $$2BibTeX$$aARTICLE
000143170 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000143170 3367_ $$00$$2EndNote$$aJournal Article
000143170 520__ $$aFecal immunochemical tests (FITs) measure hemoglobin in stool to identify individuals at risk for colorectal cancer (CRC). However, there are many different FITs, with different instructions for fecal sample collection. In routine practice, participants do not always exactly follow these instructions. We assessed the effects of violations of fecal sampling instructions on the diagnostic performance of 9 quantitative FITs.We obtained stool samples from 76 patients with CRC scheduled for surgery at 4 hospitals in Germany and 100 participants without advanced neoplasms who participated in a prospective colonoscopy screening program. We filled fecal sample tubes according to the manufacturers' instructions or with 3 violations that are likely to occur in routine practice. The diagnostic performance was assessed for a total of 6336 FIT samples (176 participants x 9 FITs x 4 sampling methods).Sample collection instructions varied widely among FITs but included 3 key components: multiple insertions of sampling rod into stool, visual check of rod for complete filling with stool, and once-only insertion of stool-filled rod into the tube. Violation of the first 2 components (inserting the rod into the stool sample only 1 time or not visually checking the rod for complete filling) reduced levels of hemoglobin measured. However, the effect on diagnostic performance was generally small. Violation of the third component (insertion of more stool into the tube than recommended) increased levels of hemoglobin measured in samples and identified more patients with CRC (increase of median sensitivity by almost 10% units) at a small loss of specificity (decrease of median specificity by 2% units), and produced highest area under the curve for detection of CRC cases for 6 FITs.Violations of fecal sampling instructions can lead to non-negligible variations in fecal hemoglobin measurements. The limited adverse effects on diagnostic performance indicate the robustness of FITs. The potential for increasing diagnostic performance by collecting more stool material should be followed up in further research.
000143170 536__ $$0G:(DE-HGF)POF3-313$$a313 - Cancer risk factors and prevention (POF3-313)$$cPOF3-313$$fPOF III$$x0
000143170 588__ $$aDataset connected to CrossRef, PubMed,
000143170 7001_ $$0P:(DE-He78)39ab513728727300b8bd91be7120b69d$$aGruner, Laura$$b1$$udkfz
000143170 7001_ $$0P:(DE-He78)01ef71f71b01a3ec3b698653fd43fe86$$aSchrotz-King, Petra$$b2$$udkfz
000143170 7001_ $$0P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2$$aBrenner, Hermann$$b3$$eLast author$$udkfz
000143170 773__ $$0PERI:(DE-600)2102638-5$$a10.1016/j.cgh.2019.03.001$$gp. S1542356519302496$$n9$$p1829-1839.e4$$tClinical gastroenterology and hepatology$$v17$$x1542-3565$$y2019
000143170 909CO $$ooai:inrepo02.dkfz.de:143170$$pVDB
000143170 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)6d4d6a0e2d726f899086ca98cd560922$$aDeutsches Krebsforschungszentrum$$b0$$kDKFZ
000143170 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)39ab513728727300b8bd91be7120b69d$$aDeutsches Krebsforschungszentrum$$b1$$kDKFZ
000143170 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)01ef71f71b01a3ec3b698653fd43fe86$$aDeutsches Krebsforschungszentrum$$b2$$kDKFZ
000143170 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2$$aDeutsches Krebsforschungszentrum$$b3$$kDKFZ
000143170 9131_ $$0G:(DE-HGF)POF3-313$$1G:(DE-HGF)POF3-310$$2G:(DE-HGF)POF3-300$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lKrebsforschung$$vCancer risk factors and prevention$$x0
000143170 9141_ $$y2019
000143170 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bCLIN GASTROENTEROL H : 2017
000143170 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS
000143170 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline
000143170 915__ $$0StatID:(DE-HGF)0310$$2StatID$$aDBCoverage$$bNCBI Molecular Biology Database
000143170 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List
000143170 915__ $$0StatID:(DE-HGF)0111$$2StatID$$aWoS$$bScience Citation Index Expanded
000143170 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection
000143170 915__ $$0StatID:(DE-HGF)1110$$2StatID$$aDBCoverage$$bCurrent Contents - Clinical Medicine
000143170 915__ $$0StatID:(DE-HGF)9905$$2StatID$$aIF >= 5$$bCLIN GASTROENTEROL H : 2017
000143170 9201_ $$0I:(DE-He78)C070-20160331$$kC070$$lKlinische Epidemiologie und Alternsforschung$$x0
000143170 9201_ $$0I:(DE-He78)C120-20160331$$kC120$$lPräventive Onkologie$$x1
000143170 980__ $$ajournal
000143170 980__ $$aVDB
000143170 980__ $$aI:(DE-He78)C070-20160331
000143170 980__ $$aI:(DE-He78)C120-20160331
000143170 980__ $$aUNRESTRICTED