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| Home > Publications database > Effect of Imperfect Compliance With Instructions for Fecal Sample Collection on Diagnostic Performance of 9 Fecal Immunochemical Tests. > print |
| 001 | 143170 | ||
| 005 | 20240229112542.0 | ||
| 024 | 7 | _ | |a 10.1016/j.cgh.2019.03.001 |2 doi |
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| 041 | _ | _ | |a eng |
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| 100 | 1 | _ | |a Gies, Anton |0 P:(DE-He78)6d4d6a0e2d726f899086ca98cd560922 |b 0 |e First author |u dkfz |
| 245 | _ | _ | |a Effect of Imperfect Compliance With Instructions for Fecal Sample Collection on Diagnostic Performance of 9 Fecal Immunochemical Tests. |
| 260 | _ | _ | |a New York, NY |c 2019 |b Elsevier Science |
| 336 | 7 | _ | |a article |2 DRIVER |
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| 520 | _ | _ | |a Fecal immunochemical tests (FITs) measure hemoglobin in stool to identify individuals at risk for colorectal cancer (CRC). However, there are many different FITs, with different instructions for fecal sample collection. In routine practice, participants do not always exactly follow these instructions. We assessed the effects of violations of fecal sampling instructions on the diagnostic performance of 9 quantitative FITs.We obtained stool samples from 76 patients with CRC scheduled for surgery at 4 hospitals in Germany and 100 participants without advanced neoplasms who participated in a prospective colonoscopy screening program. We filled fecal sample tubes according to the manufacturers' instructions or with 3 violations that are likely to occur in routine practice. The diagnostic performance was assessed for a total of 6336 FIT samples (176 participants x 9 FITs x 4 sampling methods).Sample collection instructions varied widely among FITs but included 3 key components: multiple insertions of sampling rod into stool, visual check of rod for complete filling with stool, and once-only insertion of stool-filled rod into the tube. Violation of the first 2 components (inserting the rod into the stool sample only 1 time or not visually checking the rod for complete filling) reduced levels of hemoglobin measured. However, the effect on diagnostic performance was generally small. Violation of the third component (insertion of more stool into the tube than recommended) increased levels of hemoglobin measured in samples and identified more patients with CRC (increase of median sensitivity by almost 10% units) at a small loss of specificity (decrease of median specificity by 2% units), and produced highest area under the curve for detection of CRC cases for 6 FITs.Violations of fecal sampling instructions can lead to non-negligible variations in fecal hemoglobin measurements. The limited adverse effects on diagnostic performance indicate the robustness of FITs. The potential for increasing diagnostic performance by collecting more stool material should be followed up in further research. |
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| 700 | 1 | _ | |a Schrotz-King, Petra |0 P:(DE-He78)01ef71f71b01a3ec3b698653fd43fe86 |b 2 |u dkfz |
| 700 | 1 | _ | |a Brenner, Hermann |0 P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2 |b 3 |e Last author |u dkfz |
| 773 | _ | _ | |a 10.1016/j.cgh.2019.03.001 |g p. S1542356519302496 |0 PERI:(DE-600)2102638-5 |n 9 |p 1829-1839.e4 |t Clinical gastroenterology and hepatology |v 17 |y 2019 |x 1542-3565 |
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